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|Title:||Portal hypertension in acute liver failure|
García Pagán, Juan Carlos
Bosch i Genover, Jaume
Riera, J. R.
Mas Comas, Ana M.
Bruguera i Cortada, Miquel, 1942-
Malalties del fetge
|Abstract:||Twenty five patients with acute liver failure were measured for hepatic venous pressure gradient as an index of portal pressure during the course of a transjugular liver biopsy. Hepatic venous pressure gradient ranged from 4 to 24.5 mm Hg with a mean of 12.8 (5.3) mm Hg (normal values less than 5 mm Hg). All patients but one had increased portal pressure gradient. Portal hypertension correlated with the degree of architectural distortion of the liver, as suggested by a direct correlation between hepatic venous pressure gradient and the area of reticulin collapse, evaluated by means of a morphometric analysis on Sirius red stained liver slides (r = 0.43, p less than 0.05). Hepatic venous pressure gradient was significantly higher in patients with ascites (15.1 (5) mm Hg, n = 15) or renal failure (14.4 (5.3) mm Hg, n = 16) than in those without (9.3 (3.4) mm Hg and 10.1 (4) mm Hg, respectively; p less than 0.05). Portal hypertension was associated with systemic vasodilation and a hyperkinetic circulatory state, with decreased arterial pressure, and peripheral resistance and increased cardiac output.|
|Note:||Reproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.33.7.965|
|It is part of:||Gut, 1992, vol. 33, p. 965-968|
|Appears in Collections:||Articles publicats en revistes (Medicina)|
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