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Title: | Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix intraventricular hemorrhage. |
Author: | Fernández de Gamarra-Oca L Zubiaurre Elorza, Leire Junqué i Plaja, Carme, 1955- Solana Díaz, Elisabeth Soria Pastor, Sara Vázquez, Elida Delgado, Ignacio Macaya Ruiz, Alfons Ojeda, Natalia Poca, Maria A |
Keywords: | Malalties cerebrals Desenvolupament infantil Infants prematurs Imatges per ressonància magnètica Brain diseases Child development Premature infants Magnetic resonance imaging |
Issue Date: | 28-Jan-2021 |
Publisher: | Nature Publishing Group |
Abstract: | Preterm newborns with germinal matrix-intraventricular hemorrhage (GM-IVH) are at a higher risk of evidencing neurodevelopmental alterations. Present study aimed to explore the long-term efects that GM-IVH have on hippocampal subfelds, and their correlates with memory. The sample consisted of 58 participants, including 36 preterm-born (16 with GM-IVH and 20 without neonatal brain injury), and 22 full-term children aged between 6 and 15 years old. All participants underwent a cognitive assessment and magnetic resonance imaging study. GM-IVH children evidenced lower scores in Full Intelligence Quotient and memory measures compared to their low-risk preterm and full-term peers. High-risk preterm children with GM-IVH evidenced signifcantly lower total hippocampal volumes bilaterally and hippocampal subfeld volumes compared to both low-risk preterm and full-term groups. Finally, signifcant positive correlations between memory and hippocampal subfeld volumes were only found in preterm participants together; memory and the right CA-feld correlation remained signifcant after Bonferroni correction was applied (p= .002). In conclusion, memory alterations and both global and regional volumetric reductions in the hippocampus were found to be specifcally related to a preterm sample with GM-IVH. Nevertheless, results also suggest that prematurity per se has a long-lasting impact on the association between the right CA-feld volume and memory during childhood. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-021-81802-7 |
It is part of: | Scientific Reports, 2021, vol. 11, p. 2420 |
URI: | http://hdl.handle.net/2445/186890 |
Related resource: | https://doi.org/10.1038/s41598-021-81802-7 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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