Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/186966
Title: | BDNF Val66Met gene polymorphism modulates brain activity following rTMS-induced memory impairment |
Author: | Abellaneda Pérez, Kilian Martin Trias, Pablo Cassé Perrot, Catherine Vaqué Alcázar, Lídia Lanteaume, Laura Solana Díaz, Elisabeth Babiloni, Claudio Lizio, Roberta Junqué i Plaja, Carme Bargalló Alabart, Núria Rossini, Paolo Maria Micallef, Joëlle Truillet, Romain Charles, Estelle Jouve, Elisabeth Bordet, Régis Santamaria Cano, Joan Rossi, Simone Pascual Leone, Álvaro Blin, Olivier Richardson, Jill Jovicich, Jorge Bartrés Faz, David |
Keywords: | Trastorns de la memòria Mapatge del cervell Cognició Neuroplasticitat Memory disorders Brain mapping Cognition Neuroplasticity |
Issue Date: | 1-Dec-2022 |
Publisher: | Nature Publishing Group |
Abstract: | The BDNF Val66Met gene polymorphism is a relevant factor explaining inter-individual diferences to TMS responses in studies of the motor system. However, whether this variant also contributes to TMS-induced memory efects, as well as their underlying brain mechanisms, remains unexplored. In this investigation, we applied rTMS during encoding of a visual memory task either over the left frontal cortex (LFC; experimental condition) or the cranial vertex (control condition). Subsequently, individuals underwent a recognition memory phase during a functional MRI acquisition. We included 43 young volunteers and classifed them as 19 Met allele carriers and 24 as Val/Val individuals. The results revealed that rTMS delivered over LFC compared to vertex stimulation resulted in reduced memory performance only amongst Val/Val allele carriers. This genetic group also exhibited greater fMRI brain activity during memory recognition, mainly over frontal regions, which was positively associated with cognitive performance. We concluded that BDNF Val66Met gene polymorphism, known to exert a signifcant efect on neuroplasticity, modulates the impact of rTMS both at the cognitive as well as at the associated brain networks expression levels. This data provides new insights on the brain mechanisms explaining cognitive inter-individual diferences to TMS, and may inform future, more individually-tailored rTMS interventions. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-021-04175-x |
It is part of: | Scientific Reports, 2022, vol. 12, num. 1, p. 1-11 |
URI: | http://hdl.handle.net/2445/186966 |
Related resource: | https://doi.org/10.1038/s41598-021-04175-x |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
717987.pdf | Original Article | 1.56 MB | Adobe PDF | View/Open |
Author Correction BDNF Val66Met gene polymorphism modulates brain_ScientificReports.pdf | Author correction | 663.91 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License