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http://hdl.handle.net/2445/187066
Title: | Human papillomavirus seroprevalence and seroconversion following baseline detection of nine human papillomavirus types in young women |
Author: | Brown, Darron R. Castellsagué, Xavier Ferris, Daron Garland, Suzanne M. Huh, Warner Steben, Marc Wheeler, Cosette M. Saah, Alfred Luxembourg, Alain Li, Se Velicer, Christine |
Keywords: | Papil·lomavirus Genètica humana Papillomaviruses Human genetics |
Issue Date: | 1-May-2022 |
Publisher: | Elsevier |
Abstract: | Background: Estimates of the humoral immune response to incident human papillomavirus (HPV) infections are limited. Methods: In this post hoc analysis of 3875 women aged 16-23 years from a 4-valent HPV vaccine trial (NCT00092482), HPV seroprevalence on day 1 was measured with a 9-valent HPV (HPV 6/11/16/18/31/33/45/ 52/58) competitive Luminex immunoassay and compared with cervical/external genital HPV detection by po-lymerase chain reaction. In the control group, among women who were HPV DNA-negative on day 1, sero-conversion following initial HPV detection was estimated using Kaplan-Meier methods. Results: Type-specific HPV seropositivity among women with no day 1 cervical/external genital HPV detection was 0.6%-3.6%. Women with any 9-valent HPV (9vHPV) cervical/external genital detection (796/3875; 20.5%) had concordant seropositivity ranging from 13.4% (HPV 45) to 38.5% (HPV 6). Among women in the control group who were negative for all HPV types on day 1, seroconversion by month 30 after initial detection ranged from 29% (HPV 45) to 75% (HPV 16). Conclusions: Humoral immune response to HPV is variable and dynamic, depending on type-specific exposure. This longitudinal analysis provides insight into the relationship between incident infection and seropositivity. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.tvr.2022.200236 |
It is part of: | Tumour Virus Research, 2022, vol. 13 |
URI: | http://hdl.handle.net/2445/187066 |
Related resource: | https://doi.org/10.1016/j.tvr.2022.200236 |
ISSN: | 2666-6790 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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