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http://hdl.handle.net/2445/187141
Title: | Heterocycle-Based Multicomponent Reactions in Drug Discovery: From Hit Finding to Rational Design |
Author: | Nadal Rodríguez, Pau Ghashghaei, Ouldouz Bagan Polonio, Andrea Escolano Mirón, Carmen Lavilla Grífols, Rodolfo |
Keywords: | Química farmacèutica Síntesi orgànica Compostos heterocíclics Pharmaceutical chemistry Organic synthesis Heterocyclic compounds |
Issue Date: | 23-Jun-2022 |
Publisher: | MDPI |
Abstract: | In the context of the structural complexity necessary for a molecule to selectively display a therapeutical action and the requirements for suitable pharmacokinetics, a robust synthetic approach is essential. Typically, thousands of relatively similar compounds should be prepared along the drug discovery process. In this respect, heterocycle‐based multicomponent reactions offer advantages over traditional stepwise sequences in terms of synthetic economy, as well as the fast access to chemsets to study the structure activity relationships, the fine tuning of properties, and the preparation of larger amounts for preclinical phases. In this account, we briefly summarize the scientific methodology backing the research line followed by the group. We comment on the main results, clustered according to the targets and, finally, in the conclusion section, we offer a general appraisal of the situation and some perspectives regarding future directions in academic and private research. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/biomedicines10071488 |
It is part of: | Biomedicines, 2022, vol. 10, p. 1488-1507 |
URI: | http://hdl.handle.net/2445/187141 |
Related resource: | https://doi.org/10.3390/biomedicines10071488 |
ISSN: | 2227-9059 |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
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