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Title: Cruciferous Vegetable Intake and Bulky DNA Damage within Non-Smokers and Former Smokers in the Gen-Air Study (EPIC Cohort)
Author: Peluso, Marco
Munnia, Armelle
Russo, Valentina
Galli, Andrea
Pala, Valeria
van der Schouw, Yvonne T.
Schulze, Matthias B.
Weiderpass, Elisabete
Tumino, Rosario
Saieva, Calogero
Exezarreta Pilar, Amiano
Aune, Dagfinn
Heath, Alicia K.
Aglago, Elom
Agudo, Antonio
Panico, Salvatore
Petersen, Kristina Elin Nielsen
Tjønneland, Anne
Cirera, Lluís
Rodriguez Barranco, Miguel
Katzke, Verena
Kaaks, Rudolf
Ricceri, Fulvio
Milani, Lorenzo
Vineis, Paolo
Sacerdote, Carlotta
Keywords: Assaigs clínics
Clinical trials
Issue Date: 15-Jun-2022
Publisher: MDPI AG
Abstract: Epidemiologic studies have indicated that cruciferous vegetables can influence the cancer risk; therefore, we examined with a cross-sectional approach the correlation between the frequent consumption of the total cruciferous vegetables and the formation of bulky DNA damage, a biomarker of carcinogen exposure and cancer risk, in the Gen-Air study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. DNA damage measurements were performed in the peripheral blood of 696 of those apparently healthy without cancer controls, including 379 never-smokers and 317 former smokers from seven European countries by the P-32-postlabeling assay. In the Gen-Air controls, the median intake of cruciferous vegetables was 6.16 (IQR 1.16-13.66) g/day, ranging from 0.37 (IQR 0-6.00) g/day in Spain to 11.34 (IQR 6.02-16.07) g/day in the UK. Based on this information, participants were grouped into: (a) high consumers (>20 g/day), (b) medium consumers (3-20 g/day) and (c) low consumers (<3.0 g/day). Overall, low cruciferous vegetable intake was correlated with a greater frequency of bulky DNA lesions, including benzo(a)pyrene, lactone and quinone-adducts and bulky oxidative lesions, in the adjusted models. Conversely, a high versus low intake of cruciferous vegetables was associated with a reduction in DNA damage (up to a 23% change, p = 0.032); this was particularly evident in former smokers (up to a 40% change, p = 0.008). The Generalized Linear Regression models indicated an overall Mean Ratio between the high and the low consumers of 0.78 (95% confidence interval, 0.64-0.97). The current study suggests that a higher intake of cruciferous vegetables is associated with a lower level of bulky DNA adducts and supports the potential for cancer prevention strategies through dietary habit changes aimed at increasing the consumption of cruciferous vegetables.
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It is part of: Nutrients, 2022, vol.14, num.12, p. 2477
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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