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http://hdl.handle.net/2445/188683| Title: | Human induced pluripotent stem cell-derived kidney organoids toward clinical implementations |
| Author: | Garreta, Elena Nauryzgaliyeva, Zarina Montserrat Pulido, Núria |
| Keywords: | Enginyeria biomèdica Ronyó Cèl·lules mare Biomedical engineering Kidney Stem cells |
| Issue Date: | 1-Dec-2021 |
| Abstract: | The generation of kidney organoids from human pluripotent stem cells (hPSCs) has represented a relevant scientific achievement in the organoid field. Importantly, hPSC-derived kidney organoids contain multiple nephron-like structures that exhibit some renal functional characteristics and have the capacity to respond to nephrotoxic agents. In this review, we first discuss how bioengineering approaches can help overcome current kidney organoid challenges. Next, we focus on recent works exploiting kidney organoids for drug screening and disease modeling applications. Finally, we provide a state of the art on current research toward the potential application of kidney organoids and renal cells derived from hPSCs for future renal replacement therapies. |
| Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.cobme.2021.100346 |
| It is part of: | Current Opinion in Biomedical Engineering, 2021, vol. 20, num. 100346 |
| URI: | http://hdl.handle.net/2445/188683 |
| Related resource: | https://doi.org/10.1016/j.cobme.2021.100346 |
| ISSN: | 2468-4511 |
| Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 2022_CurOpiBioEng_Human_GarretaE.pdf | 914.44 kB | Adobe PDF | View/Open |
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