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http://hdl.handle.net/2445/188952
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DC Field | Value | Language |
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dc.contributor.author | Puig, Noemí | - |
dc.contributor.author | Contreras, María Teresa | - |
dc.contributor.author | Agulló, Cristina | - |
dc.contributor.author | Martínez López, Joaquín | - |
dc.contributor.author | Oriol Bosch, Albert | - |
dc.contributor.author | Blanchard, María Jesús | - |
dc.contributor.author | Ríos, Rafael | - |
dc.contributor.author | Martín, Jesús | - |
dc.contributor.author | Iñigo, María Belén | - |
dc.contributor.author | Sureda, Anna | - |
dc.contributor.author | Hernández, Miguel Teodoro | - |
dc.contributor.author | De La Rubia, Javier | - |
dc.contributor.author | González Calle, Verónica | - |
dc.contributor.author | Krsnik, Isabel | - |
dc.contributor.author | Cabañas, Valentín | - |
dc.contributor.author | Palomera, Luis | - |
dc.contributor.author | Moraleda, José María | - |
dc.contributor.author | Bargay, Joan | - |
dc.contributor.author | Cedena, María Teresa | - |
dc.contributor.author | Paiva, Bruno | - |
dc.contributor.author | Rosiñol, Laura | - |
dc.contributor.author | Bladé, J. (Joan) | - |
dc.contributor.author | San Miguel, Jesús | - |
dc.contributor.author | Lahuerta, Juan José | - |
dc.contributor.author | Mateos, María Victoria | - |
dc.date.accessioned | 2022-09-12T11:12:13Z | - |
dc.date.available | 2022-09-12T11:12:13Z | - |
dc.date.issued | 2022-05-31 | - |
dc.identifier.issn | 2473-9537 | - |
dc.identifier.uri | http://hdl.handle.net/2445/188952 | - |
dc.description.abstract | Monitoring of the monoclonal protein (M-protein) by electrophoresis and/or immunofixation (IFE) has long been used to assess treatment response in multiple myeloma (MM). However, with the use of highly effective therapies, the M-protein becomes frequently undetectable, and more sensitive methods had to be explored. We applied IFE and mass spectrometry (EXENT&FLC-MS) in serum samples from newly diagnosed MM patients enrolled in the PETHEMA/GEM2012MENOS65 obtained at baseline (n = 223), and after induction (n = 183), autologous stem cell transplantation (n = 173), and consolidation (n = 173). At baseline, the isotypes identified with both methods fully matched in 82.1% of samples; in the rest but 2 cases, EXENT&FLC-MS provided additional information to IFE with regards to the M-protein(s). Overall, the results of EXENT&FLC-MS and IFE were concordant in >80% of cases, being most discordances due to EXENT&FLC-MS+ but IFE cases. After consolidation, IFE was not able to discriminate 2 cohorts with different median progression-free survival (PFS), but EXENT&FLC-MS did so; furthermore, among IFE patients, EXENT&FLC-MS identified 2 groups with significantly different median PFS (P = .0008). In conclusion, compared with IFE, EXENT&FLC-MS is more sensitive to detect the M-protein of patients with MM, both at baseline and during treatment, and provides a more accurate prediction of patients' outcome. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Society of Hematology | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1182/bloodadvances.2021006762 | - |
dc.relation.ispartof | Blood Advances, 2022, vol. 6, núm. 11, p. 3234-3239 | - |
dc.relation.uri | https://doi.org/10.1182/bloodadvances.2021006762 | - |
dc.rights | cc by-nc-nd (c) Puig, Noemí et al., 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Anticossos monoclonals | - |
dc.subject.classification | Espectrometria de masses | - |
dc.subject.other | Monoclonal antibodies | - |
dc.title | Mass spectrometry vs immunofixation for treatment monitoring in multiple myeloma | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-08-25T11:29:00Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9298490 | - |
dc.identifier.pmid | 35157768 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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advancesadv2021006762.pdf | 919.58 kB | Adobe PDF | View/Open |
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