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Title: Actively maintained lipid nanodomains in biomembranes
Author: Gomez, Jordi
Sagués i Mestre, Francesc
Reigada Sanz, Ramon
Keywords: Biofísica
Física mèdica
Química física
Membranes cel·lulars
Medical physics
Physical chemistry
Cell membranes
Issue Date: 2008
Publisher: The American Physical Society
Abstract: Lipid rafts, defined as domains rich in cholesterol and sphingolipids, are involved in many important plasma membrane functions. Recent studies suggest that the way cells handle membrane cholesterol is fundamental in the formation of such lateral heterogeneities. We propose to model the plasma membrane as a nonequilibrium phase-separating system where cholesterol is dynamically incorporated and released. The model shows how cellular regulation of membrane cholesterol may determine the nanoscale lipid organization when the lipid mixture is close to a phase separation boundary, providing a plausible mechanism for raft formation in vivo.
Note: Reproducció del document publicat a:
It is part of: Physical Review E, 2008, vol. 77, núm. 2, p. 021907-1-021907-5
ISSN: 1063-651X
Appears in Collections:Articles publicats en revistes (Ciència dels Materials i Química Física)

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