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http://hdl.handle.net/2445/189320| Title: | The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation |
| Author: | Ginex, Tiziana Marco Marín, Clara Wieczór, Miłosz Mata, Carlos P. Krieger, James Ruiz Rodriguez, Paula López Redondo, Maria Luisa Francés Gómez, Clara Melero, Roberto Sánchez Sorzano, Carlos Óscar Martínez, Marta Gougeard, Nadine Forcada Nadal, Alicia Zamora Caballero, Sara Gozalbo Rovira, Roberto Sanz Frasquet, Carla Arranz, Rocío Bravo, Jeronimo Rubio, Vicente Marina, Alberto Geller, Ron Comas, Iñaki Gil, Carmen Coscolla, Mireia Orozco López, Modesto Llácer, José Luis Carazo, Jose Maria The IBV Covid19 Pipeline |
| Keywords: | SARS-CoV-2 Mutació (Biologia) SARS-CoV-2 Mutation (Biology) |
| Issue Date: | 11-Jul-2022 |
| Abstract: | The S:A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared in the Delta subvariant AY.4.2, raising questions about its specific effect on viral infection. We report combined serological, functional, structural and computational studies characterizing the impact of this mutation. Our results reveal that S:A222V promotes an increased RBD opening and slightly increases ACE2 binding as compared to the parent S:D614G clade. Finally, S:A222V does not reduce sera neutralization capacity, suggesting it does not affect vaccine effectiveness. |
| Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.ppat.1010631 |
| It is part of: | Plos Pathogens, 2022, vol. 18, num. 7 |
| URI: | http://hdl.handle.net/2445/189320 |
| Related resource: | https://doi.org/10.1371/journal.ppat.1010631 |
| ISSN: | 1553-7374 |
| Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
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|---|---|---|---|---|
| journal.ppat.1010631.pdf | 4.07 MB | Adobe PDF | View/Open |
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