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http://hdl.handle.net/2445/189808
Title: | Mdscs in Infectious diseases: regulation, roles, and readjustment |
Author: | Dorhoi, Anca Glaría Percaz, Estíbaliz Garcia-Tellez, Thalia Nieuwenhuizen, Natalie E. Zelinskyy, Gennadiy Favier, Benoit Singh, Anurag Ehrchen, Jan Gujer, Cornelia Münz, Christian Saraiva, Margarida Sohrabi, Yhaya Sousa, Ana E. Delputte, Peter Müller-Trutwin, Michaela Valledor Fernández, Annabel |
Keywords: | Immunosupressió Infeccions Virus oncogènics Immunosuppression Infections Oncogenic viruses |
Issue Date: | 19-Dec-2018 |
Publisher: | Springer Verlag |
Abstract: | Many pathogens, ranging from viruses to multicellular parasites, promote expansion of MDSCs, which are myeloid cells that exhibit immunosuppressive features. The roles of MDSCs in infection depend on the class and virulence mechanisms of the pathogen, the stage of the disease, and the pathology associated with the infection. This work compiles evidence supported by functional assays on the roles of different subsets of MDSCs in acute and chronic infections, including pathogen-associated malignancies, and discusses strategies to modulate MDSC dynamics to benefit the host. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1007/s00262-018-2277-y |
It is part of: | Cancer Immunology Immunotherapy, 2018, vol. 68, num. 4, p. 673-685 |
URI: | http://hdl.handle.net/2445/189808 |
Related resource: | https://doi.org/10.1007/s00262-018-2277-y |
ISSN: | 0340-7004 |
Appears in Collections: | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) |
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