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Title: | Prodromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthood |
Author: | Verdolini, Norma Borràs, Roger Sparacino, Giulio Garriga, Marina Sagué Vilavella, Maria Madero, Santiago Palacios Garrán, Roberto Serra Navarro, Maria Forte, Maria Florencia Salagre, Estela Aedo, Alberto Salgado Pineda, Pilar Montoro Salvatierra, Irene Sánchez Gistau, Vanessa Pomarol-Clotet, Edith Ramos Quiroga, Josep Antoni Carvalho, André F. García Rizo, Clemente Undurraga Fourcade, Juan Pablo Reinares, María Martinez Aran, Anabel Bernardo Arroyo, Miquel Vieta i Pascual, Eduard, 1963- Pacchiarotti, Isabella Amoretti Guadall, Silvia |
Keywords: | Psicosi Trastorn bipolar Factors de risc en les malalties Psicosi en els adolescents Adults Símptomes Psychoses Manic-depressive illness Risk factors in diseases Psychoses in adolescence Adulthood Symptoms |
Issue Date: | 25-Feb-2022 |
Publisher: | John Wiley & Sons |
Abstract: | Objective: This study was aimed at identifying differences in the prodromal symptoms and their duration, risk factors and markers of vulnerability in patients presenting a first episode mania (FEM) or psychosis (FEP) with onset in late adolescence or adulthood in order to guide tailored treatment strategies. Methods: Patients with a FEM or FEP underwent a clinical assessment. Prodromes were evaluated with the Bipolar Prodrome Symptom Scale-Retrospective (BPSS-R). Chi-squared tests were conducted to assess specific prodromal symptoms, risk factors or markers of vulnerability between groups. Significant prodromal symptoms were entered in a stepwise forward logistic regression model. The probabilities of a gradual versus rapid onset pattern of the prodromes were computed with logistic regression models. Results: The total sample included 108 patients (FEM = 72, FEP = 36). Social isolation was associated with the prodromal stage of a FEP whilst Increased energy or goal-directed activity with the prodrome to a FEM. Physically slowed down presented the most gradual onset whilst Increased energy presented the most rapid. The presence of obstetric complications and difficulties in writing and reading during childhood were risk factors for FEP. As for markers of vulnerability, impairment in premorbid adjustment was characteristic of FEP patients. No specific risk factor or marker of vulnerability was identified for FEM. Conclusion: Early characteristics differentiating FEP from FEM were identified. These findings might help shape early identification and preventive intervention programmes. |
Note: | Reproducció del document publicat a: https://doi.org/10.1111/acps.13415 |
It is part of: | Acta Psychiatrica Scandinavica, 2022, vol. 146, num. 1, p. 36-50 |
URI: | http://hdl.handle.net/2445/190776 |
Related resource: | https://doi.org/10.1111/acps.13415 |
ISSN: | 0001-690X |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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