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http://hdl.handle.net/2445/190789
Title: | Brain atrophy pattern in de novo Parkinsons disease with probable RBD associated with cognitive impairment |
Author: | Oltra, Javier Uribe, Carme Segura i Fàbregas, Bàrbara Campabadal, Anna Inguanzo, Anna Monté Rubio, Gemma C. Pardo, Jèssica Martí Domènech, Ma. Josep Compta, Yaroslau Valldeoriola Serra, Francesc Junqué i Plaja, Carme, 1955- Iranzo, Alex |
Keywords: | Malaltia de Parkinson Malalties cerebrals Trastorns del son Trastorns de la cognició Imatges per ressonància magnètica Parkinson's disease Brain diseases Sleep disorders Cognition disorders Magnetic resonance imaging |
Issue Date: | 24-May-2022 |
Publisher: | Springer Nature |
Abstract: | Rapid eye movement sleep behavior disorder (RBD) is associated with high likelihood of prodromal Parkinson's disease (PD) and is common in de novo PD. It is associated with greater cognitive impairment and brain atrophy. However, the relation between structural brain characteristics and cognition remains poorly understood. We aimed to investigate subcortical and cortical atrophy in de novo PD with probable RBD (PD-pRBD) and to relate it with cognitive impairment. We analyzed volumetry, cortical thickness, and cognitive measures from 79 PD-pRBD patients, 126 PD without probable RBD patients (PD-non pRBD), and 69 controls from the Parkinson's Progression Markers Initiative (PPMI). Regression models of cognition were tested using magnetic resonance imaging measures as predictors. We found lower left thalamus volume in PD-pRBD compared with PD-non pRBD. Compared with controls, PD-pRBD group showed atrophy in the bilateral putamen, left hippocampus, left amygdala, and thinning in the right superior temporal gyrus. Specific deep gray matter nuclei volumes were associated with impairment in global cognition, phonemic fluency, processing speed, and visuospatial function in PD-pRBD. In conclusion, cognitive impairment and gray matter atrophy are already present in de novo PD-pRBD. Thalamus, hippocampus, and putamen volumes were mainly associated with these cognitive deficits. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41531-022-00326-7 |
It is part of: | npj Parkinson's Disease, 2022, vol. 8, num. 1, p. 60 |
URI: | http://hdl.handle.net/2445/190789 |
Related resource: | https://doi.org/10.1038/s41531-022-00326-7 |
ISSN: | 2373-8057 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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