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http://hdl.handle.net/2445/190850
Title: | LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries |
Author: | Graupera, Isabel Thiele, Maja Ma, Ann T. Serra-Burriel, Miquel Pich, Judith Fabrellas i Padrès, Núria Caballeria, Llorenç de Knegt, Robert J. Grgurevic, Ivica Reichert, Mathias Roulot, Dominique Schattenberg, Jörn M. Pericàs, Juan M. Angeli, Paolo Tsochatzis, Emmanuel A. Guha, Indra Neil García Retortillo, Montserrat Morillas Cunill, Rosa María Hernández, Rosario Hoyo, Jordi Fuentes, Matilde Madir, Anita Juanola, Adrià Soria, Anna Juan, Marta Carol, Marta Diaz, Alba Detlefsen, Sönke Torán, Pere Fournier, Céline Llorca, Anne Newsome, Phillip N. Manns, Michael de Koning, Harry J. Serra-Burriel, Feliu Cucchietti, Fernando Arslanow, Anita Korenjak, Marko van Kleef, Laurens Falcó, Josep Lluis Kamath, Patrick S. Karlsen, Tom H. Castera, Laurent Lammert, Frank Krag, Aleksander Ginès i Gibert, Pere |
Keywords: | Biòpsia Cirrosi hepàtica Diagnòstic per la imatge Biopsy Hepatic cirrhosis Diagnostic imaging |
Issue Date: | 1-Jul-2022 |
Publisher: | BioMed Central |
Abstract: | Background: The development of liver cirrhosis is usually an asymptomatic process until late stages when complications occur. The potential reversibility of the disease is dependent on early diagnosis of liver fibrosis and timely targeted treatment. Recently, the use of non-invasive tools has been suggested for screening of liver fibrosis, especially in subjects with risk factors for chronic liver disease. Nevertheless, large population-based studies with cost-effectiveness analyses are still lacking to support the widespread use of such tools. The aim of this study is to investigate whether non-invasive liver stiffness measurement in the general population is useful to identify subjects with asymptomatic, advanced chronic liver disease. Methods: This study aims to include 30,000 subjects from eight European countries. Subjects from the general population aged ≥ 40 years without known liver disease will be invited to participate in the study either through phone calls/letters or through their primary care center. In the first study visit, subjects will undergo bloodwork as well as hepatic fat quantification and liver stiffness measurement (LSM) by vibration-controlled transient elastography. If LSM is ≥ 8 kPa and/or if ALT levels are ≥1.5 x upper limit of normal, subjects will be referred to hospital for further evaluation and consideration of liver biopsy. The primary outcome is the percentage of subjects with LSM ≥ 8kPa. In addition, a health economic evaluation will be performed to assess the cost-effectiveness and budget impact of such an intervention. The project is funded by the European Commission H2020 program. Discussion: This study comes at an especially important time, as the burden of chronic liver diseases is expected to increase in the coming years. There is consequently an urgent need to change our current approach, from diagnosing the disease late when the impact of interventions may be limited to diagnosing the disease earlier, when the patient is asymptomatic and free of complications, and the disease potentially reversible. Ultimately, the LiverScreen study will serve as a basis from which diagnostic pathways can be developed and adapted to the specific socio-economic and healthcare conditions in each country. |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/s12889-022-13724-6 |
It is part of: | BMC Public Health, 2022, num. 22, p. 1385 |
URI: | http://hdl.handle.net/2445/190850 |
Related resource: | https://doi.org/10.1186/s12889-022-13724-6 |
ISSN: | 1471-2458 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil) |
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