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http://hdl.handle.net/2445/191606| Title: | A multicomponent reaction platform towards multimodal near-infrared BODIPY dyes for STED and fluorescence lifetime imaging |
| Author: | Fernandez, Antonio Kielland, Nicola Makda, Ashraff Carragher, Neil González-García, M. Carmen Espinar-Barranco, Laura González-Vera, Juan Antonio Orte, Ángel Lavilla Grífols, Rodolfo Vendrell, Marc |
| Keywords: | Química farmacèutica Síntesi orgànica Pharmaceutical chemistry Organic synthesis |
| Issue Date: | 28-Aug-2022 |
| Publisher: | MDPI |
| Abstract: | We report a platform combining multicomponent reaction synthesis and automated cell-based screening to develop biocompatible NIR-BODIPY fluorophores. From a library of over 60 fluorophores, we optimised compound NIRBD-62c as a multimodal probe with suitable properties for STED super-resolution and fluorescence lifetime imaging. Furthermore, we employed NIRBD-62c for imaging trafficking inside cells and to examine how pharmacological inhibitors can alter the vesicular traffic between intracellular compartments and the plasma membrane. |
| Note: | Reproducció del document publicat a: https://doi.org/10.1039/d2cb00168c |
| It is part of: | Biomedicines, 2022 |
| URI: | http://hdl.handle.net/2445/191606 |
| Related resource: | https://doi.org/10.1039/d2cb00168c |
| ISSN: | 2227-9059 |
| Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 724484.pdf | 2.93 MB | Adobe PDF | View/Open |
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