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Title: | GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates |
Author: | Roca Ayats, Neus Balcells Comas, Susana Garcia Giralt, Natàlia Falcó-Mascaró, Maite Martinez-Gil, Nuria Abril Ferrando, Josep Francesc, 1970- Urreizti, Roser Dopazo, Joaquin Quesada Gómez, José Manuel Nogués Solán, Xavier Mellibovsky, Leonardo Prieto-Alhambra, Daniel Dunford, James E. Javaid, Muhammad K. Russell, R. Graham Grinberg Vaisman, Daniel Raúl Diez Pérez, Adolfo |
Keywords: | Mutació (Biologia) Fractures Músculs Mutation (Biology) Fractures Muscles |
Issue Date: | 4-May-2017 |
Publisher: | Massachusetts Medical Society |
Abstract: | Atypical femoral fractures have been associated with long-term bisphosphonate treatment.1,2 However, the underlying mechanisms remain obscure. We studied three sisters who had atypical femoral fractures after receiving various oral bisphosphonates for 6 years. Two of the sisters had a single fracture (at the ages of 64 and 73 years), and one had bilateral fractures (one at the age of 60 years and the other at the age of 61 years). Given the low incidence of atypical femoral fractures in the general population (5.9 per 10,000 person-years),3 we hypothesized that these sisters might have an underlying genetic background that contributed to these fractures. |
Note: | Reproducció del document publicat a: https://doi.org/10.1056/NEJMc1612804 |
It is part of: | New England Journal of Medicine, 2017, vol. 376, num. 18, p. 1794-1795 |
URI: | http://hdl.handle.net/2445/192645 |
Related resource: | https://doi.org/10.1056/NEJMc1612804 |
ISSN: | 0028-4793 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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