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http://hdl.handle.net/2445/193026| Title: | The estructural role of SARS-Cov-2 genetic background on the emergence and scucess of Spike mutations: the case of the Spike A222 mutation |
| Author: | Ginex, Tiziana Marco-Marín, Clara Wieczor, Miłosz Mata, Carlos P. Krieger, James Ruiz-Rodriguez, Paula López-Redondo, Maria Luisa Francésc-Gómez, Clara Melero, Roberta Sánchez-Sorzano, Carlos Oscar Martínez, Marta Gougeard, Nadine Forcada-Nadal, Alicia Zamora-Caballero, Sara Gozalbo-Rovira, Roberto Sanz-Frasquet, Carla Arranz, Rocío Bravo, Jeronimo Rubio, Vicente Marina, Alberto Geller, Ron Comas, Iñaki Gil, Carmen Coscolla, Mireia Orozco López, Modesto Llácer, José Luis Carazo, Jose-Maria |
| Keywords: | SARS-CoV-2 Infeccions Mutació (Biologia) Vacunes SARS-CoV-2 Infections Mutation (Biology) Vaccines |
| Issue Date: | 11-Jul-2022 |
| Publisher: | Public Library of Science (PLoS) |
| Abstract: | The S:A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared in the Delta subvariant AY.4.2, raising questions about its specific effect on viral infection. We report combined serological, functional, structural and computational studies character-izing the impact of this mutation. Our results reveal that S:A222V promotes an increased RBD opening and slightly increases ACE2 binding as compared to the parent S:D614G clade. Finally, S:A222V does not reduce sera neutralization capacity, suggesting it does not affect vaccine effectiveness |
| Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.ppat.1010631 |
| It is part of: | PLoS Pathogens, 2022, vol. 18, num. 7 |
| URI: | http://hdl.handle.net/2445/193026 |
| Related resource: | https://doi.org/10.1371/journal.ppat.1010631 |
| ISSN: | 1553-7366 |
| Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
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