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http://hdl.handle.net/2445/194162| Title: | Efficient AntiMycolata agents by increasing the lipophilicity of known antibiotics through multicomponent reactions |
| Author: | Trejo, Angela Masdeu, Carme Serrano-Pérez, Irene Pedrola, Marina Juanola, Narcís Ghashgaei, Ouldouz Jiménez Galisteo, Mª Guadalupe Lavilla Grífols, Rodolfo Palacios, Francisco Alonso, Concepción Viñas, Miquel |
| Keywords: | Antibiòtics Medicaments Micobacteris Antibiotics Drugs Mycobacteria |
| Issue Date: | 3-Jan-2023 |
| Publisher: | MDPI |
| Abstract: | New antibiotic agents were prepared using Povarov and Ugi multicomponent reactions upon the known drugs sulfadoxine and dapsone. The prepared derivatives, with increased lipophilicity, showed improved efficiency against Mycolata bacteria. Microbiological guidance for medicinal chemistry is a powerful tool to design new and effective antimicrobials. In this case, the readily synthesized compounds open new possibilities in the search for antimicrobials active on mycolic acid-containing bacteria. |
| Note: | Reproducció del document publicat a: https://doi.org/10.3390/antibiotics12010083 |
| It is part of: | Antibiotics, 2023, vol. 12, p. 83 |
| URI: | http://hdl.handle.net/2445/194162 |
| Related resource: | https://doi.org/10.3390/antibiotics12010083 |
| ISSN: | 2079-6382 |
| Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Patologia i Terapèutica Experimental) |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 727886.pdf | 3.55 MB | Adobe PDF | View/Open |
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