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http://hdl.handle.net/2445/194378
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DC Field | Value | Language |
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dc.contributor.author | Garrido, Alicia | - |
dc.contributor.author | Pérez Sisqués, Leticia | - |
dc.contributor.author | Simonet, Cristina | - |
dc.contributor.author | Campoy Campos, Genís | - |
dc.contributor.author | Solana Balaguer, Júlia | - |
dc.contributor.author | Martín Flores, Núria | - |
dc.contributor.author | Fernández, Manel | - |
dc.contributor.author | Soto, Marta | - |
dc.contributor.author | Obiang, Donina | - |
dc.contributor.author | Camara, Ana | - |
dc.contributor.author | Valldeoriola Serra, Francesc | - |
dc.contributor.author | Muñoz, Esteban | - |
dc.contributor.author | Compta, Yaroslau | - |
dc.contributor.author | Pérez Navarro, Esther | - |
dc.contributor.author | Alberch i Vié, Jordi | - |
dc.contributor.author | Tolosa, Eduardo | - |
dc.contributor.author | Martí Domènech, Ma. Josep | - |
dc.contributor.author | Ezquerra, Mario | - |
dc.contributor.author | Malagelada Grau, Cristina | - |
dc.contributor.author | Fernández Santiago, Rubén | - |
dc.date.issued | 2022-11 | - |
dc.identifier.issn | 0364-5134 | - |
dc.identifier.uri | http://hdl.handle.net/2445/194378 | - |
dc.description.abstract | The purpose of this study was to investigate whether differential phosphorylation states of blood markers can identify patients with LRRK2 Parkinson's disease (PD). We assessed phospho(P)-Ser-935-LRRK2 and P-Ser-473-AKT levels in peripheral blood cells from patients with G2019S LRRK2-associated PD (L2PD, n = 31), G2019S LRRK2 non-manifesting carriers (L2NMC, n = 26), idiopathic PD (iPD, n = 25), and controls (n = 40, total n = 122). We found no differences at P-Ser-935-LRRK2 between groups but detected a specific increase of P-Ser-473-AKT levels in all G2019S carriers, either L2PD or L2NMC, absent in iPD. Although insensitive to LRRK2 inhibition, our study identifies P-Ser-473-AKT as an endogenous candidate biomarker for peripheral inflammation in G2019S carriers using accessible blood cells. ANN NEUROL 2022;92:888-894. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1002/ana.26469 | - |
dc.relation.ispartof | Annals of Neurology, 2022, vol. 92, num. 5, p. 888-894 | - |
dc.relation.uri | https://doi.org/10.1002/ana.26469 | - |
dc.rights | cc by nc-nd (c) Garrido, Alicia et al., 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Malaltia de Parkinson | - |
dc.subject.classification | Mutació (Biologia) | - |
dc.subject.classification | Proteïnes portadores | - |
dc.subject.classification | Cèl·lules sanguínies | - |
dc.subject.classification | Nervis perifèrics | - |
dc.subject.other | Parkinson's disease | - |
dc.subject.other | Mutation (Biology) | - |
dc.subject.other | Carrier proteins | - |
dc.subject.other | Blood cells | - |
dc.subject.other | Peripheral nerves | - |
dc.title | Increased Phospho-AKT in Blood Cells from LRRK2 G2019S Mutation Carriers | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 730022 | - |
dc.date.updated | 2023-03-01T13:26:14Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 35929078 | - |
Appears in Collections: | Articles publicats en revistes (Biomedicina) Articles publicats en revistes (Institut de Neurociències (UBNeuro)) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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730022.pdf | 788.78 kB | Adobe PDF | View/Open |
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