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Title: | Azithromycin to Prevent Pertussis in Household Contacts, Catalonia and Navarre, Spain, 2012-2013 |
Author: | Álvarez, Josep Godoy i García, Pere Plans Rubio, Pedro Camps, Neus Carol, Mónica Carmona i Parcerisa, Glòria Solano, Rubén Rius, Cristina Minguell, Sofía Barrabeig i Fabregat, Irene Sala Farré, Maria Rosa Rodríguez, Raquel Garcia Cenoz, Manuel Muñoz Almagro, Carmen Domínguez, Angela Transmission of Pertussis in Households Working Group |
Keywords: | Tos ferina Terapèutica Whooping cough Therapeutics |
Issue Date: | 1-Nov-2020 |
Publisher: | Centers for Disease Control and Prevention |
Abstract: | We retrospectively assessed the effectiveness of azithromycin in preventing transmission of pertussis to a patient's household contacts. We also considered the duration between symptom onset in the primary patient and azithromycin administration. We categorized contacts into 4 groups: those treated within <7 days, 8-14 days, 15-21 days, and >21 days after illness onset in the primary patient. We studied 476 primary index patients and their 1,975 household contacts, of whom 4.5% were later identified as having pertussis. When contacts started chemoprophylaxis within <21 days after the primary patient's symptom onset, the treatment was 43.9% effective. Chemoprophylaxis started >14 days after primary patient's symptom onset was less effective. We recommend that contacts of persons with pertussis begin chemoprophylaxis within <14 days after primary patient's symptom onset. |
Note: | Reproducció del document publicat a: https://doi.org/10.3201/eid2611.181418 |
It is part of: | Emerging Infectious Diseases, 2020, vol. 26, num. 11, p. 2678-2684 |
URI: | http://hdl.handle.net/2445/194952 |
Related resource: | https://doi.org/10.3201/eid2611.181418 |
ISSN: | 1080-6040 |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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