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http://hdl.handle.net/2445/195173
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DC Field | Value | Language |
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dc.contributor.author | Dominguez Valentin, Mev | - |
dc.contributor.author | Crosbie, Emma J. | - |
dc.contributor.author | Engel, Christoph | - |
dc.contributor.author | Aretz, Stefan | - |
dc.contributor.author | Macrae, Finlay | - |
dc.contributor.author | Winship, Ingrid | - |
dc.contributor.author | Capellá, G. (Gabriel) | - |
dc.contributor.author | Thomas, Huw | - |
dc.contributor.author | Nakken, Sigve | - |
dc.contributor.author | Hovig, Eivind | - |
dc.contributor.author | Nielsen, Maartje | - |
dc.contributor.author | Sijmons, Rolf H. | - |
dc.contributor.author | Bertario, Lucio | - |
dc.contributor.author | Bonanni, Bernardo | - |
dc.contributor.author | Tibiletti, Maria Grazia | - |
dc.contributor.author | Cavestro, Giulia Martina | - |
dc.contributor.author | Mints, Miriam | - |
dc.contributor.author | Gluck, Nathan | - |
dc.contributor.author | Katz, Lior | - |
dc.contributor.author | Heinimann, Karl | - |
dc.contributor.author | Vaccaro, Carlos A. | - |
dc.contributor.author | Green, Kate | - |
dc.contributor.author | Lalloo, Fiona | - |
dc.contributor.author | Hill, James | - |
dc.contributor.author | Schmiegel, Wolff | - |
dc.contributor.author | Vangala, Deepak | - |
dc.contributor.author | Perne, Claudia | - |
dc.contributor.author | Strauß, Hans Georg | - |
dc.contributor.author | Tecklenburg, Johanna | - |
dc.contributor.author | Holinski-Feder, Elke | - |
dc.contributor.author | Steinke-Lange, Verena | - |
dc.contributor.author | Mecklin, Jukka-Pekka | - |
dc.contributor.author | Plazzer, John-Paul | - |
dc.contributor.author | Pineda Riu, Marta | - |
dc.contributor.author | Navarro, Matilde | - |
dc.contributor.author | Brunet, Joan | - |
dc.contributor.author | Kariv, Revital | - |
dc.contributor.author | Rosner, Guy | - |
dc.contributor.author | Piñero, Tamara Alejandra | - |
dc.contributor.author | González, María Laura | - |
dc.contributor.author | Kalfayan, Pablo | - |
dc.contributor.author | Ryan, Neil A. J. | - |
dc.contributor.author | Ten Broeke, Sanne W. | - |
dc.contributor.author | Jenkins, Mark A. | - |
dc.contributor.author | Sunde, Lone | - |
dc.contributor.author | Bernstein, Inge | - |
dc.contributor.author | Burn, John | - |
dc.contributor.author | Greenblatt, Marc | - |
dc.contributor.author | de Vos Tot Nederveen Cappel, Wouter H. | - |
dc.contributor.author | Della Valle, Adriana | - |
dc.contributor.author | Lopez Kostner, Francisco | - |
dc.contributor.author | Alvarez Valenzuela, Karin | - |
dc.contributor.author | Büttner, Reinhard | - |
dc.contributor.author | Görgens, Heike | - |
dc.contributor.author | Morak, Monika | - |
dc.contributor.author | Holzapfel, Stefanie | - |
dc.contributor.author | Hüneburg, Robert | - |
dc.contributor.author | von Knebel Doeberitz, Magnus | - |
dc.contributor.author | Loeffler, Markus | - |
dc.contributor.author | Rahner, Nils | - |
dc.contributor.author | Weitz, Jürgen | - |
dc.contributor.author | Pylvänäinen, Kirsi | - |
dc.contributor.author | Renkonen Sinisalo, Laura | - |
dc.contributor.author | Lepistö, Anna | - |
dc.contributor.author | Auranen, Annika | - |
dc.contributor.author | Hopper, John L. | - |
dc.contributor.author | Ko Win, Aung | - |
dc.contributor.author | Haile, Robert W. | - |
dc.contributor.author | Lindor, Noralane M. | - |
dc.contributor.author | Gallinger, Steven | - |
dc.contributor.author | Le Marchand, Loïc | - |
dc.contributor.author | Newcomb, Polly A. | - |
dc.contributor.author | Figueiredo, Jane C. | - |
dc.contributor.author | Thibodeau, Stephen N. | - |
dc.contributor.author | Therkildsen, Christina | - |
dc.contributor.author | Okkels, Henrik | - |
dc.contributor.author | Ketabi, Zohreh | - |
dc.contributor.author | Denton, Oliver G. | - |
dc.contributor.author | Rødland, Einar A. | - |
dc.contributor.author | Vasen, Hans | - |
dc.contributor.author | Neffa, Florencia | - |
dc.contributor.author | Esperon, Patricia | - |
dc.contributor.author | Tjandra, Douglas | - |
dc.contributor.author | Möslein, Gabriela | - |
dc.contributor.author | Sampson, Julian R. | - |
dc.contributor.author | Evans, D. Gareth | - |
dc.contributor.author | Seppälä, Toni T. | - |
dc.contributor.author | Møller, Pål | - |
dc.date.accessioned | 2023-03-13T17:34:47Z | - |
dc.date.available | 2023-03-13T17:34:47Z | - |
dc.date.issued | 2020-12-01 | - |
dc.identifier.issn | 1098-3600 | - |
dc.identifier.uri | http://hdl.handle.net/2445/195173 | - |
dc.description.abstract | Purpose: To determine impact of risk-reducing hysterectomy and bilateral salpingo-oophorectomy (BSO) on gynecological cancer incidence and death in heterozygotes of pathogenic MMR (path_MMR) variants. Methods: The Prospective Lynch Syndrome Database was used to investigate the effects of gynecological risk-reducing surgery (RRS) at different ages. Results: Risk-reducing hysterectomy at 25 years of age prevents endometrial cancer before 50 years in 15%, 18%, 13%, and 0% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 heterozygotes and death in 2%, 2%, 1%, and 0%, respectively. Risk-reducing BSO at 25 years of age prevents ovarian cancer before 50 years in 6%, 11%, 2%, and 0% and death in 1%, 2%, 0%, and 0%, respectively. Risk-reducing hysterectomy at 40 years prevents endometrial cancer by 50 years in 13%, 16%, 11%, and 0% and death in 1%, 2%, 1%, and 0%, respectively. BSO at 40 years prevents ovarian cancer before 50 years in 4%, 8%, 0%, and 0%, and death in 1%, 1%, 0%, and 0%, respectively. Conclusion: Little benefit is gained by performing RRS before 40 years of age and premenopausal BSO in path_MSH6 and path_PMS2 heterozygotes has no measurable benefit for mortality. These findings may aid decision making for women with LS who are considering RRS. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American College of Medical Genetics and Genomics | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41436-020-01029-1 | - |
dc.relation.ispartof | Genetics in Medicine, 2020, vol. 27, num. 4, p. 705-712 | - |
dc.relation.uri | https://doi.org/10.1038/s41436-020-01029-1 | - |
dc.rights | cc by (c) Dominguez Valentin, Mev et al., 2020 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Malalties hereditàries | - |
dc.subject.classification | Cirurgia ginecològica | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Genetic diseases | - |
dc.subject.other | Gynecologic surgery | - |
dc.title | Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 706835 | - |
dc.date.updated | 2023-03-13T17:34:47Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33257847 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Clíniques) |
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706835.pdf | 713.16 kB | Adobe PDF | View/Open |
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