Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/196042
Title: | Functional brain connectivity prior to the COVID-19 outbreak moderates the effects of coping and perceived stress on mental health changes. A first year of COVID-19 pandemic follow-up study. |
Author: | Cabello Toscano, María Vaqué Alcázar, Lídia Cattaneo, Gabriele Solana Sánchez, Javier Bayes Marin, Ivet Abellaneda Pérez, Kilian Macià Bros, Dídac Mulet-Pons, Lídia Portellano Ortiz, Cristina Fullana, Miquel A. Oleaga Zufiría, Laura González, Sofía Bargalló Alabart, Núria Tormos, José María Pascual Leone, Álvaro Bartrés Faz, David |
Keywords: | COVID-19 Cervell Salut mental Estrès Ansietat Depressió psíquica COVID-19 Brain Mental health Stress Anxiety Mental depression |
Issue Date: | 20-Aug-2022 |
Publisher: | Elsevier Ltd |
Abstract: | Background: The COVID-19 pandemic provides a unique opportunity to investigate the psychological impact of a global major adverse situation. Our aim was to examine, in a longitudinal prospective study, the demographic, psychological, and neurobiological factors associated with interindividual differences in resilience to the mental health impact of the pandemic. Methods: We included 2023 healthy participants (age: 54.32 ± 7.18 years, 65.69% female) from the Barcelona Brain Health Initiative cohort. A linear mixed model was used to characterize the change in anxiety and depression symptoms based on data collected both pre-pandemic and during the pandemic. During the pandemic, psychological variables assessing individual differences in perceived stress and coping strategies were obtained. In addition, in a subsample (n = 433, age 53.02 ± 7.04 years, 46.88% female) with pre-pandemic resting-state functional magnetic resonance imaging available, the system segregation of networks was calculated. Multivariate linear models were fitted to test associations between COVID-19-related changes in mental health and demographics, psychological features, and brain network status. Results: The whole sample showed a general increase in anxiety and depressive symptoms after the pandemic onset, and both age and sex were independent predictors. Coping strategies attenuated the impact of perceived stress on mental health. The system segregation of the frontoparietal control and default mode networks were found to modulate the impact of perceived stress on mental health. Conclusions: Preventive strategies targeting the promotion of mental health at the individual level during similar adverse events in the future should consider intervening on sociodemographic and psychological factors as well as their interplay with neurobiological substrates. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.bpsc.2022.08.005 |
It is part of: | Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2022, vol. 8, num. 2, p. 200-209 |
URI: | http://hdl.handle.net/2445/196042 |
Related resource: | https://doi.org/10.1016/j.bpsc.2022.08.005 |
ISSN: | 2451-9022 |
Appears in Collections: | Articles publicats en revistes (ISGlobal) Articles publicats en revistes (Institut de Neurociències (UBNeuro)) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
725391.pdf | 931.54 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License