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http://hdl.handle.net/2445/197012
Title: | Oral anticoagulants (NOAC and VKA) in chronic thromboembolic pulmonary hypertension |
Author: | Humbert, Marc Simonneau, Gérald Pittrow, David Delcroix, Marion Pepke-Zaba, Joanna Langleben, David Mielniczuk, Lisa M. Escribano Subias, Pilar Snijder, Repke J. Barberà i Mir, Joan Albert Klotsche, Jens Meier, Christian Hoeper, Marius M |
Keywords: | Hipertensió pulmonar Malalties cròniques Anticoagulants (Medicina) Efectes secundaris dels medicaments Vitamines K Pulmonary hypertension Chronic diseases Anticoagulants (Medicine) Drug side effects Vitamin K |
Issue Date: | 11-Feb-2022 |
Publisher: | Elsevier |
Abstract: | EXPERT was an international, multicenter, prospective, uncontrolled, non-interventional cohort study in patients with pulmonary hypertension treated with riociguat. Patients were followed for 1-4 years, and the primary outcomes were adverse events (AEs) and serious AEs (SAEs), including embolic/thrombotic and hemorrhagic events. Here we report data on patients with chronic thromboembolic pulmonary hypertension (CTEPH) receiving a vitamin K antagonist (VKA; n = 683) or a non-vitamin K antagonist oral anticoagulant (NOAC; n = 198) at baseline. AEs and SAEs were reported in 438 patients (64.1%) and 257 patients (37.6%), respectively, in the VKA group, and in 135 patients (68.2%) and 74 patients (37.4%) in the NOAC group. Exposure-adjusted hemorrhagic event rates were similar in the two groups, while exposure-adjusted embolic and/or thrombotic event rates were higher in the NOAC group, although the numbers of events were small. Further studies are required to determine the long-term effects of anticoagulation strategies in CTEPH. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.healun.2022.02.002 |
It is part of: | Journal of Heart and Lung Transplantation, 2022, vol. 41, num. 6, p. 716-721 |
URI: | http://hdl.handle.net/2445/197012 |
Related resource: | https://doi.org/10.1016/j.healun.2022.02.002 |
ISSN: | 1053-2498 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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