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Title: | Inflammatory processes involved in the alteration of liver function biomarkers in adult hospitalized patients treated with parenteral nutrition |
Author: | Llop Talaverón, Josep Manuel Suárez-Lledó Grande, Ana Leiva Badosa, Elisabet Bas Minguet, Jordi Climent Martí, Joan Poyatos Cantón, Elisabet Badia Tahull, María B. |
Keywords: | Fetge Alimentació parenteral Parenteral feeding Liver |
Issue Date: | 27-Jan-2023 |
Publisher: | Frontiers Media |
Abstract: | IntroductionLiver damage has been associated with the accumulation of phytosterols (PS) in patients treated with parenteral nutrition (PN). We aimed to study the association of inflammatory markers with liver function biomarker (LFB) alterations in patients treated with PN containing PS. Materials and methodsProspective observational study. Simple linear and stepwise multiple linear regression tests and interactions were performed. ResultsNineteen patients were included. In the multivariable model, determinations based on LFBs as dependent and phytosterols (and their fractions) as independent variables showed an association between increases in gamma-glutamyltransferase (GGT) and lanosterol (p < 0.001), stigmasterol (p < 0.001), interleukin-10 (IL-10) x total phytosterols (Phyt) (p < 0.009), tumor necrosis factor-alpha (TNF-alpha) x Phyt (p < 0.002), IL-10 x sitosterol (p < 0.002), TNF-alpha x sitosterol (p < 0.001), IL-10 x campesterol (p < 0.033), IL-10 (p < 0.006 and p < 0.015), TNF-alpha (p < 0.048 and p < 0.027). Increases in alanine aminotransferase (ALT) were associated with Phyt (p < 0.006), lanosterol (p < 0.016), C-reactive protein (CRP) x campesterol (p < 0.001), interleukin-6 (IL-6) x stigmasterol (p < 0.030), CRP (p < 0.08), and IL-6 (p < 0.042). Alkaline phosphatase (AP) increases were associated with CRP (p < 0.002). DiscussionInflammation in the presence of plasmatic PS seems to have a synergistic effect in impairing liver function, mainly altering GGT but also ALT. |
Note: | Reproducció del document publicat a: https://doi.org/10.3389/fnut.2023.1034481 |
It is part of: | Frontiers in Nutrition, 2023, vol. 10 |
URI: | http://hdl.handle.net/2445/197200 |
Related resource: | https://doi.org/10.3389/fnut.2023.1034481 |
ISSN: | 2296-861X |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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