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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/197660
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dc.contributor.authorOrtiz-Maldonado Gibson, Valentín-
dc.contributor.authorFrigola, Gerard-
dc.contributor.authorEspañol Rego, Marta-
dc.contributor.authorBalagué, Olga-
dc.contributor.authorMartínez Cibrian, Nuria-
dc.contributor.authorMagnano, Laura-
dc.contributor.authorGiné Soca, Eva-
dc.contributor.authorPascal i Capdevila, Mariona-
dc.contributor.authorCorrea, Juan G.-
dc.contributor.authorMartínez Roca, Alexandra-
dc.contributor.authorCid, Joan-
dc.contributor.authorLozano Molero, Miguel-
dc.contributor.authorVillamor i Casas, Neus-
dc.contributor.authorBenitez Ribas, Daniel-
dc.contributor.authorEsteve Comas, Jordi-
dc.contributor.authorLópez Guillermo, Armando-
dc.contributor.authorCampo Güerri, Elias-
dc.contributor.authorUrbano Ispizua, Álvaro-
dc.contributor.authorJuan, Manel-
dc.contributor.authorDelgado, Julio (Delgado González)-
dc.date.accessioned2023-05-08T09:43:51Z-
dc.date.available2023-05-08T09:43:51Z-
dc.date.issued2022-01-31-
dc.identifier.issn2234-943X-
dc.identifier.urihttp://hdl.handle.net/2445/197660-
dc.description.abstractCART19 cells are emerging as an alternative therapy for patients with chronic lymphocytic leukemia (CLL). Here we report the outcome of nine consecutive patients with CLL treated with ARI-0001 CART19 cells, six of them with Richter’s transformation (RT). One patient with RT never received therapy. The cytokine release syndrome rate was 87.5% (12.5% grade ≥3). Neurotoxicity was not observed in any patient. All patients experienced absolute B-cell aplasia, and seven (87.5%) responded to therapy. With a median follow-up of 5.6 months, two patients with RT experienced a CD19-negative relapse. In conclusion, ARI-0001 cell therapy was feasible, safe, and effective in patients with high risk CLL or RT-
dc.format.extent7 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3389/fonc.2022.828471-
dc.relation.ispartofFrontiers In Oncology, 2022, vol.12, num. 828471-
dc.relation.urihttps://doi.org/10.3389/fonc.2022.828471-
dc.rightscc by (c) Ortiz Maldonado, Valentín et al., 2022-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.sourceArticles publicats en revistes (Medicina)-
dc.subject.classificationLeucèmia limfocítica crònica-
dc.subject.classificationTeràpia cel·lular-
dc.subject.otherChronic lymphocytic leukemia-
dc.subject.otherCellular therapy-
dc.titleResults of ARI-0001 CART19 Cells in Patients With Chronic Lymphocytic Leukemia and Richter's Transformation-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.date.updated2023-05-02T07:59:08Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.idimarina9298925-
dc.identifier.pmid35174095-
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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