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Title: | Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson’s Disease |
Author: | Santos García, Diego Laguna, Ariadna Hernández Vara, Jorge Deus Fonticoba, Teresa de Cores Bartolomé, Carlos Feal Painceiras, Maria J. Íñiguez Alvarado, Maria Cristina García Díaz, Iago Jesús, Silvia Boungiorno, Maria Teresa Planellas, Lluís Cosgaya, Marina García Caldentey, Juan Caballol, Núria Legarda, Ines Cabo, Iria López Manzanares, Lydia González Aramburu, Isabel Ávila Rivera, Maria A. Gómez Mayordomo, Víctor Nogueira, Víctor Puente, Víctor Dotor García-Soto, Julio Borrué, Carmen Solano Vila, Berta Álvarez Sauco, María Vela, Lydia Escalante, Sonia Cubo, Esther Carrillo Padilla, Francisco Castrillo, Juan C. Martínez Sánchez Alonso, Pilar Alonso Losada, Maria G. López Ariztegui, Nuria Gastón, Itziar Kulisevsky, Jaime Menéndez González, Manuel Seijo, Manuel Rúiz Martínez, Javier Valero, Caridad Kurtis, Mónica González Ardura, Jessica Alonso Redondo, Ruben Ordás, Carlos López Díaz, Luis M. Mcafee, Darrian Martinez Martin, Pablo Mir, Pablo COPPADIS Study Group |
Keywords: | Malaltia de Parkinson Factors sexuals en les malalties Parkinson's disease Sex factors in disease |
Issue Date: | 7-Feb-2023 |
Publisher: | MDPI AG |
Abstract: | Background and objective: Sex plays a role in Parkinson's disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysis were conducted. Univariate analyses and general linear model repeated measure were used. Results: At baseline, data from 681 PD patients (mean age 62.54 +/- 8.93) fit the criteria for analysis. Of them, 410 (60.2%) were males and 271 (39.8%) females. There were no differences between the groups in mean age (62.36 +/- 8.73 vs. 62.8 +/- 9.24; p = 0.297) or in the time from symptoms onset (5.66 +/- 4.65 vs. 5.21 +/- 4.11; p = 0.259). Symptoms such as depression (p < 0.0001), fatigue (p < 0.0001), and pain (p < 0.00001) were more frequent and/or severe in females, whereas other symptoms such as hypomimia (p < 0.0001), speech problems (p < 0.0001), rigidity (p < 0.0001), and hypersexuality (p < 0.0001) were more noted in males. Women received a lower levodopa equivalent daily dose (p = 0.002). Perception of quality of life was generally worse in females (PDQ-39, p = 0.002; EUROHIS-QOL8, p = 0.009). After the two-year follow-up, the NMS burden (Non-Motor Symptoms Scale total score) increased more significantly in males (p = 0.012) but the functional capacity (Schwab and England Activities of Daily Living Scale) was more impaired in females (p = 0.001). Conclusion: The present study demonstrates that there are important sex differences in PD. Long-term prospective comparative studies are needed. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/jcm12041329 |
It is part of: | Journal of Clinical Medicine, 2023, vol. 12, num. 4 |
URI: | http://hdl.handle.net/2445/197671 |
Related resource: | https://doi.org/10.3390/jcm12041329 |
ISSN: | 2077-0383 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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