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http://hdl.handle.net/2445/197785
Title: | Stereotactic body radiotherapy versus surgery for lung metastases from colorectal cancer: single-institution results |
Author: | Garcia Exposito, Nerea Ramos Izquierdo, Ricard Navarro Perez, Valentin Molina, Kevin Arnaiz, Maria Dolores Padrones, Susana Ruffinelli, José Carlos Santos, Cristina Guedea Edo, Ferran Navarro Martin, Arturo |
Keywords: | Càncer colorectal Metàstasi Mastectomia Radioteràpia Colorectal cancer Metastasis Mastectomy Radiotherapy |
Issue Date: | 13-Feb-2023 |
Publisher: | MDPI |
Abstract: | Background: Surgery and stereotactic body radiotherapy (SBRT) are two of the options available as local treatments for pulmonary oligometastases from colorectal cancer (CRC). We hypothesized that SBRT would have, at least, a similar local control rate to surgery. Methods: We identified an initial cohort of 100 patients with CRC who received SBRT or surgery for lung metastases. This was then narrowed down to 75 patients: those who underwent surgery (n = 50) or SBRT (n = 25) as their first local thoracic treatment between 1 January 2004 and 29 December 2017. The Kaplan-Meier method was used to calculate lung-progression-free survival (L-PFS) and overall survival (OS). Results: The 1 and 2-year L-PFS was 85% and 70% in the surgical group and 87% and 71% in the SBRT group, respectively (p = 0.809). No significant differences were found between the two groups in terms of OS. The biologically effective dose (BED), age and initial CRC stage did not have a significant effect on local control or survival. No grade 3 or above acute- or late-toxicity events were reported. Conclusions: These results add retrospective evidence that SBRT and surgery have similar results in terms of OS and local control in patients with lung oligometastases from CRC. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/cancers15041195 |
It is part of: | Cancers, 2023, vol. 15, num. 4, p. 1195 |
URI: | http://hdl.handle.net/2445/197785 |
Related resource: | https://doi.org/10.3390/cancers15041195 |
ISSN: | 2072-6694 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Patologia i Terapèutica Experimental) |
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