Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/198322
Title: | The Endocannabinoid System as a Target in Cancer: Status and Future Perspectives |
Author: | Moreno Guillén, Estefanía Cavic, Milena Canela Campos, Enric I. |
Keywords: | Càncer Terapèutica Cancer Therapeutics |
Issue Date: | 14-May-2023 |
Publisher: | Springer Nature |
Citation: | Moreno, E., Cavic, M., Canela, E.I. (2023). The Endocannabinoid System as a Target in Cancer: Status and Future Perspectives. In: Rezaei, N. (eds) Handbook of Cancer and Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-80962-1_276-1 |
Abstract: | The endocannabinoid system (ECS) represents a complex network of different molecules as cannabinoid receptors, endocannabinoid ligands, and the enzymatic machinery that drives their metabolism, as well as cells and pathways that use endocannabinoid signaling. It is important for the regulation of most vital biochemical processes contributing to and overall homeostasis state. As such, it is ambiguously implicated in both the development of cancer and its suppression, as well as its progression and interaction with current anti-cancer therapeutics. This work will review the main ECS components and their discovery, structure, pharmacological properties, and significance in various physiological and pathological states and focus on the current burden of evidence available from open-access databases, experimental data, and expert reviews which offer future directions for its use in the oncological setting. The vast potential of the translationally significant information of the so-called endocannabinoidome is currently being explored in many ongoing clinically oriented research studies as well as clinical trials. Previously acquired pharmacological data from its historical application in pain alleviation and as a general palliative agent in oncology will be useful for drug repurposing scenarios, aiming to speed up its possible clinical applications, after decades of carrying the stigma of an ethically and legally compromised target. |
Note: | Reproducció del document publicat a: https://doi.org/10.1007/978-3-030-80962-1 |
It is part of: | Capítol del llibre: Rezaei, N. (eds) (2023). Handbook of Cancer and Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-80962-1 |
URI: | http://hdl.handle.net/2445/198322 |
Related resource: | https://doi.org/10.1007/978-3-030-80962-1_276-1 |
Appears in Collections: | Llibres / Capítols de llibre (Bioquímica i Biomedicina Molecular) Llibres / Capítols de llibre (Institut de Biomedicina (IBUB)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
512948_0_En_276-1_Chapter_Author.pdf | 561.34 kB | Adobe PDF | View/Open Request a copy |
Document embargat fins el 14-5-2025
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.