Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/198562
Title: | Specific biomarker comparison in current smokers, e-cigarette users, and non-smokers |
Author: | Melero Ollonarte, Juan Luis Lidón Moyano, Cristina Perez Ortuño, Raúl Fu Balboa, Marcela Ballbè i Gibernau, Montse Martín Sánchez, Juan Carlos González Barrón, Adrián Cartanyà Hueso, Àurea Pascual, José A. Fernández Muñoz, Esteve Martínez Sánchez, Jose M. |
Keywords: | Cigarretes electròniques Marcadors bioquímics Tabac Fumadors Electronic cigarettes Biochemical markers Tobacco Cigarette smokers |
Issue Date: | 19-Jan-2023 |
Publisher: | Elsevier BV |
Abstract: | Introduction: This study aims to address the existing gap in the literature, while adding evidence, by comparing tobacco-specific biomarkers (cotinine and nitrosamines: NNK, NNAL, NNN), and other biomarkers of e-cigarette use (humectants: glycerol, 1,2-PD, 1,3-PD) according to five study groups. Methods: A pooling analysis including two different studies was conducted. In both analyses, we took saliva samples from smokers (n = 409) and non-smokers (n = 154), dual tobacco and e-cig users (n = 92), exclusive e-cig user with nicotine (n = 158), and exclusive e-cig users without nicotine (n = 38). We analyzed and compared the geometric means (GM) and geometric standard deviations (GSD) of the concentration of tobacco-specific biomarkers, and e-cigarette biomarkers among groups. We used log-linear models adjusted for sex and age to model the change percentage and their 95% confidence intervals. Results: Cotinine was significantly higher in nicotine consumers and in e-cigarette users without nicotine when compared to non-smokers. TSNAs were generally significantly lower in non-smokers and higher in nicotine consumers. NNN and NNAL were lower in e-cigarette users with nicotine comparted to smokers, and NNN was higher in e-cigarette users without nicotine when compared to non-smokers. No differences were found in humectant biomarkers between e-cigarette groups. Conclusions: Although there was a reduction in TSNAs in e-cigarette exclusive users compared to smokers, and a reduction of cotinine concentrations in e-cigarette exclusive users without nicotine compared to smokers, there are still high levels of these biomarkers when compared to non-smokers, which may be a clue towards the harmful effect of e-cigarettes. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.addbeh.2023.107616 |
It is part of: | Addictive Behaviors, 2023, vol. 140, p. 107616 |
URI: | http://hdl.handle.net/2445/198562 |
Related resource: | https://doi.org/10.1016/j.addbeh.2023.107616 |
ISSN: | 1873-6327 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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Melero-Ollonarte.pdf | 1.39 MB | Adobe PDF | View/Open Request a copy |
Document embargat fins el 19-1-2025
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