Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/199385
Title: | Organs-on-Chips: Trends and Challenges in Advanced Systems Integration |
Author: | Mughal, Sheeza López Muñoz, Gerardo A. Fernández Costa, Juan M. Cortés Resendiz, Armando De Chiara, Francesco Ramón Azcón, Javier |
Keywords: | Bioenginyeria Cultiu cel·lular Bioengineering Cell culture |
Issue Date: | 25-Oct-2022 |
Publisher: | Wiley |
Abstract: | Organ-on-chip platforms combined with high-throughput sensing technology allow bridging gaps in information presented by 2D cultures modeled on static microphysiological systems. While these platforms do not aim to replicate whole organ systems with all physiological nuances, they try to mimic relevant structural, physiological, and functional features of organoids and tissues to best model disease and/or healthy states. The advent of this platform has not only challenged animal testing but has also presented the opportunity to acquire real-time, high-throughput data about the pathophysiology of disease progression by employing biosensors. Biosensors allow monitoring of the release of relevant biomarkers and metabolites as a result of physicochemical stress. It, therefore, helps conduct quick lead validation to achieve personalized medicine objectives. The organ-on-chip industry is currently embarking on an exponential growth trajectory. Multiple pharmaceutical and biotechnology companies are adopting this technology to enable quick patient-specific data acquisition at substantially low costs. |
Note: | Postprint del document publicat a: https://doi.org/10.1002/admi.202201618 |
It is part of: | Advanced Materials Interfaces, 2022, vol. 9 |
URI: | http://hdl.handle.net/2445/199385 |
Related resource: | https://doi.org/10.1002/admi.202201618 |
ISSN: | 2196-7350 |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
Files in This Item:
File | Description | Size | Format | |
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2022_AdvMatInt_OrganOnChips_RamonJ_postprint.pdf | 4.79 MB | Adobe PDF | View/Open |
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