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Title: | Structural Heart Alterations in Brugada Syndrome: Is it Really a Channelopathy? A Systematic Review |
Author: | Oliva, Antonio Grassi, Simone Pinchi, Vilma Cazzato, Francesca Coll, Mònica Alcalde, Mireia Vallverdú Prats, Marta Pérez Serra, Alexandra Martínez Barrios, Estefanía Cesar, Sergi Iglesias, Anna Cruzalegui, José Hernández, Clara Fiol, Victoria Arbelo, Elena Díez Escuté, Nuria Arena, Vincenzo Brugada Terradellas, Josep, 1958- Sarquella Brugada, Georgia Brugada, Ramon Campuzano, Óscar |
Keywords: | Mort sobtada Malalties del cor Sudden death Heart diseases |
Issue Date: | 28-Jul-2022 |
Publisher: | MDPI |
Abstract: | Brugada syndrome (BrS) is classified as an inherited cardiac channelopathy attributed to dysfunctional ion channels and/or associated proteins in cardiomyocytes rather than to structural heart alterations. However, hearts of some BrS patients exhibit slight histologic abnormalities, suggesting that BrS could be a phenotypic variant of arrhythmogenic cardiomyopathy. We performed a systematic review of the literature following Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement (PRISMA) criteria. Our comprehensive analysis of structural findings did not reveal enough definitive evidence for reclassification of BrS as a cardiomyopathy. The collection and comprehensive analysis of new cases with a definitive BrS diagnosis are needed to clarify whether some of these structural features may have key roles in the pathophysiological pathways associated with malignant arrhythmogenic episodes. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/jcm11154406 |
It is part of: | Journal Of Clinical Medicine, 2022, vol. 11, num. 15 |
URI: | http://hdl.handle.net/2445/199555 |
Related resource: | https://doi.org/10.3390/jcm11154406 |
ISSN: | 2077-0383 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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