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Title: | Differences in Inflammatory Cytokine Profile in Obesity-Associated Asthma: Effects of Weight Loss |
Author: | Bantulà, Marina Tubita, Valeria Roca Ferrer, Jordi Mullol i Miret, Joaquim Valero, Antonio Bobolea, Irina Pascal i Capdevila, Mariona Hollanda Ramírez, Ana M. de Vidal, Josep Picado Vallés, César Arismendi, Ebymar |
Keywords: | Asma Obesitat Asthma Obesity |
Issue Date: | 29-Jun-2022 |
Publisher: | MDPI |
Abstract: | Obesity and asthma are associated with systemic inflammation maintained by mediators released by adipose tissue and lung. This study investigated the inflammatory serum mediator profile in obese subjects (O) (n = 35), non-obese asthma (NOA) patients (n = 14), obese asthmatics (OA) (n = 21) and healthy controls (HC) (n = 33). The effect of weight loss after bariatric surgery (BS) was examined in 10 OA and 31 O subjects. We analyzed serum markers including leptin, adiponectin, TGF-?1, TNFR2, MCP-1, ezrin, YKL-40, ST2, IL-5, IL-9, and IL-18. Compared with HC subjects, the O group showed increased levels of leptin, TGF-?1, TNFR2, MCP-1, ezrin, YKL-40, and ST2; the OA group presented increased levels of MCP-1, ezrin, YKL-40, and IL-18, and the NOA group had increased levels of ezrin, YKL-40, IL-5, and IL-18. The higher adiponectin/leptin ratio in NOA with respect to OA subjects was the only significant difference between the two groups. IL-9 was the only cytokine with significantly higher levels in OA with respect to O subjects. TNFR2, ezrin, MCP-1, and IL-18 concentrations significantly decreased in O subjects after BS. O, OA, and NOA showed distinct patterns of systemic inflammation. Leptin and adiponectin are regulated in asthma by obesity-dependent and-independent mechanisms. Combination of asthma and obesity does not result in significant additive effects on circulating cytokine levels. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/jcm11133782 |
It is part of: | Journal Of Clinical Medicine, 2022, vol. 11, num. 13 |
URI: | http://hdl.handle.net/2445/199582 |
Related resource: | https://doi.org/10.3390/jcm11133782 |
ISSN: | 2077-0383 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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Differences in Inflammatory Cytokine Profile in_ClinicalMedicine.pdf | 1.05 MB | Adobe PDF | View/Open |
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