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http://hdl.handle.net/2445/200590
Title: | The neuroanatomical basis of panic disorder and social phobia in schizophrenia: a voxel based morphometric study |
Author: | Picado, Marisol Carmona, Susanna Hoekzema, Elseline Pailhez, Guillem Bergé, Daniel Mané, Anna Fauquet, Jordi Hilferty, Joseph Moreno, Ana Cortizo, Romina Vilarroya, Oscar Bulbena, Antoni |
Keywords: | Esquizofrènia Fòbia social Trastorns de pànic Imatges per ressonància magnètica Schizophrenia Social phobia Panic disorders Magnetic resonance imaging |
Issue Date: | 16-Mar-2015 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | [eng] Objective: It is known that there is a high prevalence of certain anxiety disorders among schizophrenic patients, especially panic disorder and social phobia. However, the neural underpinnings of the comorbidity of such anxiety disorders and schizophrenia remain unclear. Our study aims to determine the neuroanatomical basis of the co-occurrence of schizophrenia with panic disorder and social phobia. Methods: Voxel-based morphometry was used in order to examine brain structure and to measure between-group differences, comparing magnetic resonance images of 20 anxious patients, 20 schizophrenic patients, 20 schizophrenic patients with comorbid anxiety, and 20 healthy control subjects. Results: Compared to the schizophrenic patients, we observed smaller grey-matter volume (GMV) decreases in the dorsolateral prefrontal cortex and precentral gyrus in the schizophrenic-anxiety group. Additionally, the schizophrenic group showed significantly reduced GMV in the dorsolateral prefrontal cortex, precentral gyrus, orbitofrontal cortex, temporal gyrus and angular/inferior parietal gyrus when compared to the control group. Conclusions: Our findings suggest that the comorbidity of schizophrenia with panic disorder and social phobia might be characterized by specific neuroanatomical and clinical alterations that may be related to maladaptive emotion regulation related to anxiety. Even thought our findings need to be replicated, our study suggests that the identification of neural abnormalities involved in anxiety, schizophrenia and schizophrenia-anxiety may lead to an improved diagnosis and management of these conditions. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0119847 |
It is part of: | PLoS One, 2015, vol. 10, num. 3, p. 1-15 |
URI: | http://hdl.handle.net/2445/200590 |
Related resource: | https://doi.org/10.1371/journal.pone.0119847 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Llengües i Literatures Modernes i Estudis Anglesos) |
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