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Title: | Staging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life |
Author: | Santos García, Diego Deus Fonticoba, Teresa de Cores Bartolomé, Carlos Feal Painceiras, Maria J. Íñiguez Alvarado, Maria Cristina García Díaz, Iago Jesús, Silvia Buongiorno, Maria Teresa Planellas, Lluís Cosgaya, Marina García Caldentey, Juan Caballol, Nuria Legarda, Ines Hernández Vara, Jorge Cabo, Iria López Manzanares, Lydia González Aramburu, Isabel Ávila Rivera, Maria A. Gómez Mayordomo, Víctor Nogueira, Víctor Puente, Víctor Dotor García-Soto, Julio Borrué, Carmen Solano Vila, Berta Álvarez Sauco, María Vela, Lydia Escalante, Sonia Cubo, Esther Carrillo Padilla, Francisco Martínez Castrillo, Juan C. Sánchez Alonso, Pilar Alonso Losada, Maria G. López Ariztegui, Nuria Gastón, Itziar Kulisevsky, Jaime Menéndez González, Manuel Seijo, Manuel Ruiz Martínez, Javier Valero, Caridad Kurtis, Mónica González Ardura, Jessica Alonso Redondo, Ruben Ordás, Carlos López Díaz, Luis M. Mcafee, Darrian Calopa, Matilde Carrillo, Fátima Escamilla Sevilla, Francisco Freire Alvarez, Eric Gómez Esteban, Juan Carlos García Ramos, Rocío Luquín, María Rosario Isabel Martínez Torres, Irene Sesar Ignacio, Ángel Martinez Martin, Pablo Mir, Pablo COPPADIS Study Group |
Keywords: | Malaltia de Parkinson Qualitat de vida Símptomes Parkinson's disease Quality of life Symptoms |
Issue Date: | 6-Mar-2023 |
Publisher: | IOS Press |
Abstract: | Background: Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD). Objective: Our aim was to apply the MNCD classification in a cohort of PD patients for the first time and also to analyze the correlation with quality of life (QoL) and disease severity. Methods: Data from the baseline visit of PD patients recruited from 35 centers in Spain from the COPPADIS cohort from January 2016 to November 2017 were used to apply the MNCD classification. Three instruments were used to assess QoL: 1) the 39-item Parkinson's disease Questionnaire [PDQ-39]); PQ-10; the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Results: Four hundred and thirty-nine PD patients (62.05 +/- 7.84 years old; 59% males) were included. MNCD stage was: stage 1, 8.4% (N = 37); stage 2, 62% (N = 272); stage 3, 28.2% (N = 124); stage 4-5, 1.4% (N = 6). A more advanced MNCD stage was associated with a higher score on the PDQ39SI (p < 0.0001) and a lower score on the PQ-10 (p < 0.0001) and EUROHIS-QOL8 (p < 0.0001). In many other aspects of the disease, such as disease duration, levodopa equivalent daily dose, motor symptoms, non-motor symptoms, and autonomy for activities of daily living, an association between the stage and severity was observed, with data indicating a progressive worsening related to disease progression throughout the proposed stages. Conclusion: Staging PD according to the MNCD classification correlated with QoL and disease severity. The MNCD could be a proper tool to monitor the progression of PD. |
Note: | Reproducció del document publicat a: https://doi.org/10.3233/JPD-225073 |
It is part of: | Journal of Parkinson's Disease, 2023, vol. 13, num. 3, p. 379-402 |
URI: | http://hdl.handle.net/2445/200872 |
Related resource: | https://doi.org/10.3233/JPD-225073 |
ISSN: | 1877-718X |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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