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http://hdl.handle.net/2445/200901
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DC Field | Value | Language |
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dc.contributor.author | Alemany Navarro, M. | - |
dc.contributor.author | Tubío Fungueiriño, M. | - |
dc.contributor.author | Diz de Almeida, S. | - |
dc.contributor.author | Cruz, R. | - |
dc.contributor.author | Lombroso, A. | - |
dc.contributor.author | Real, E. | - |
dc.contributor.author | Soria, V. | - |
dc.contributor.author | Bertolín, S. | - |
dc.contributor.author | Fernández Prieto, M. | - |
dc.contributor.author | Alonso, P. | - |
dc.contributor.author | Menchón Magriñá, José Manuel | - |
dc.contributor.author | Carracedo, A. | - |
dc.contributor.author | Segalàs, C. | - |
dc.date.accessioned | 2023-07-19T11:11:20Z | - |
dc.date.available | 2023-07-19T11:11:20Z | - |
dc.date.issued | 2023-07-01 | - |
dc.identifier.issn | 1573-2517 | - |
dc.identifier.uri | http://hdl.handle.net/2445/200901 | - |
dc.description.abstract | Background: The study of Obsessive-Compulsive Disorder (OCD) genomics has primarily been tackled by Genome-wide association studies (GWAS), which have encountered troubles in identifying replicable single nucleotide polymorphisms (SNPs). Endophenotypes have emerged as a promising avenue of study in trying to elucidate the genomic bases of complex traits such as OCD.Methods: We analyzed the association of SNPs across the whole genome with the construction of visuospatial information and executive performance through four neurocognitive variables assessed by the Rey-Osterrieth Complex Figure Test (ROCFT) in a sample of 133 OCD probands. Analyses were performed at SNP- and genelevel.Results: No SNP reached genome-wide significance, although there was one SNP almost reaching significant association with copy organization (rs60360940; P = 9.98E-08). Suggestive signals were found for the four variables at both SNP- (P < 1E-05) and gene-levels (P < 1E-04). Most of the suggestive signals pointed to genes and genomic regions previously associated with neurological function and neuropsychological traits. Limitations: Our main limitations were the sample size, which was limited to identify associated signals at a genome-wide level, and the composition of the sample, more representative of rather severe OCD cases than a population-based OCD sample with a broad severity spectrum.Conclusions: Our results suggest that studying neurocognitive variables in GWAS would be more informative on the genetic basis of OCD than the classical case/control GWAS, facilitating the genetic characterization of OCD and its different clinical profiles, the development of individualized treatment approaches, and the improvement of prognosis and treatment response. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.jad.2023.04.060 | - |
dc.relation.ispartof | Journal of Affective Disorders, 2023, vol. 333, p. 365-376 | - |
dc.relation.uri | https://doi.org/10.1016/j.jad.2023.04.060 | - |
dc.rights | cc by (c) Alemany Navarro, M. et al., 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Genòmica | - |
dc.subject.classification | Neurosi obsessiva | - |
dc.subject.classification | Neurociència cognitiva | - |
dc.subject.other | Genomics | - |
dc.subject.other | Obsessive-compulsive disorder | - |
dc.subject.other | Cognitive neuroscience | - |
dc.title | The genomics of visuospatial neurocognition in obsessive-compulsive disorder: A preliminary GWAS | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-07-19T09:36:00Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 37094658 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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1-s2.0-S0165032723005219-main (1).pdf | 1.57 MB | Adobe PDF | View/Open |
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