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http://hdl.handle.net/2445/201040
Title: | Control of cell adhesion and compartmentalization in the intestinal epithelium |
Author: | Solanas Fuster, Guiomar Batlle, Eduard |
Keywords: | Malalties inflamatòries intestinals Fisiologia Inflammatory bowel diseases Physiology |
Issue Date: | 29-Jul-2011 |
Publisher: | Elsevier |
Abstract: | Continuous cell renewal in the intestinal mucosa occurs without disrupting the integrity of the epithelial layer. Despite the restrictions imposed by strong cell-to-cell adhesions, epithelial intestinal cells migrate constantly between tissue compartments. Alterations in cell adhesion and compartmentalization play key roles in diseases of the intestine. In particular, decreased E-cadherin-mediated adhesion during inflammatory bowel disease and loss of EphB/ephrin-B-mediated compartmentalization in colorectal cancer have recently emerged as key players of these prevalent pathologies. Here we will review our current knowledge on how cell-to-cell adhesion, migration and cell positioning are coordinated in the intestinal epithelium. We will highlight what the in vivo genetic analysis of intestinal epithelium has taught us about the complex regulation of cell adhesion and migration in homeostasis and disease. © 2011 Elsevier Inc. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.yexcr.2011.07.019 |
It is part of: | Experimental Cell Research, 2011, vol. 317, num. 19, p. 2695-2701 |
URI: | http://hdl.handle.net/2445/201040 |
Related resource: | https://doi.org/10.1016/j.yexcr.2011.07.019 |
ISSN: | 1090-2422 |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
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Solanas et al_Exp Cell Res_2011.pdf | 220.07 kB | Adobe PDF | View/Open |
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