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http://hdl.handle.net/2445/201089
Title: | Association of occupational heat exposure and colorectal cancer in the MCC-Spain study |
Author: | Hinchliffe, Alice Kogevinas, Manolis Molina de la Torre, Antonio José Moreno Aguado, Víctor Aragonès Sanz, Núria Castaño Vinyals, Gemma Jiménez Moleón, José Juan Gómez Acebo, Inés Ederra, María Amiano, Pilar Molina Barceló, Ana Fernández Tardón, Guillermo Alguacil, Juan Chirlaque, María Dolores Hernández Segura, Natalia Pérez Gómez, Beatriz Pollan, Marina Turner, Michelle C. |
Keywords: | Altes temperatures Càncer colorectal High temperatures Colorectal cancer |
Issue Date: | 19-Feb-2023 |
Publisher: | Scandinavian Journal of Work, Environment and Health |
Abstract: | Objective Heat exposure and heat stress/strain is a concern for many workers. There is increasing interest in potential chronic health effects of occupational heat exposure, including cancer risk. We examined potential associations of occupational heat exposure and colorectal cancer (CRC) risk in a large Spanish multi-case- control study.Methods We analyzed data on 1198 histologically confirmed CRC cases and 2690 frequency-matched controls. The Spanish job-exposure matrix, MatEmEsp, was used to assign heat exposure estimates to the lifetime occupa-tions of participants. Three exposure indices were assessed: ever versus never exposed, cumulative exposure and duration (years). We estimated odds ratios (OR) and 95% confidence intervals (CI) using unconditional logistic regression adjusting for potential confounders.Results Overall, there was no association of ever, compared with never, occupational heat exposure and CRC (OR 1.09, 95% CI 0.92-1.29). There were also no associations observed according to categories of cumulative exposure or duration, and there was no evidence for a trend. There was no clear association of ever occupational heat exposure and CRC in analysis conducted among either men or women when analyzed separately. Positive associations were observed among women in the highest categories of cumulative exposure (OR 1.81, 95% CI 1.09-3.03) and duration (OR 2.89, 95% CI 1.50-5.59) as well as some evidence for a trend (P<0.05).Conclusion Overall, this study provides no clear evidence for an association between occupational heat exposure and CRC. |
Note: | Reproducció del document publicat a: https://doi.org/10.5271/sjweh.4082 |
It is part of: | Scandinavian Journal of Work, Environment & Health, 2023, vol. 49, num. 3, p. 211-221 |
URI: | http://hdl.handle.net/2445/201089 |
Related resource: | https://doi.org/10.5271/sjweh.4082 |
ISSN: | 0355-3140 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (ISGlobal) |
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