Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/201422
Title: | Food processing and cancer risk in Europe: results from the prospective EPIC cohort study |
Author: | Kliemann, Nathalie Rauber, Fernanda Bertazzi Levy, Renata Viallon, Vivian Vamos, Eszter P Cordova, Reynalda Freisling, Heinz Casagrande, Corinne Nicolas, Genevieve Aune, Dagfinn Tsilidis, Konstantinos K. Heath, Alicia Schulze, Matthias B. Jannasch, Franziska Srour, Bernard Kaaks, Rudolf Rodriguez Barranco, Miguel Tagliabue, Giovanna Agudo, Antonio Panico, Salvatore Ardanaz, Eva Chirlaque, María Dolores Vineis, Paolo Tumino, Rosario Perez Cornago, Aurora Munk Andersen, Julie Louise Tjønneland, Anne Skeie, Guri Weiderpass, Elisabete Monteiro, Carlos Augusto Gunter, Marc J. Millett, Christopher Huybrechts, Inge |
Keywords: | Manipulació dels aliments Malalties d'origen alimentari Càncer Factors de risc en les malalties Estudi de casos Food handling Foodborne diseases Cancer Risk factors in diseases Case studies |
Issue Date: | 1-Mar-2023 |
Publisher: | Elsevier BV |
Abstract: | Background Food processing has been hypothesised to play a role in cancer development; however, data from large-scale epidemiological studies are scarce. This study investigated the association between dietary intake according to amount of food processing and risk of cancer at 25 anatomical sites using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Methods This study used data from the prospective EPIC cohort study, which recruited participants between March 18, 1991, and July 2, 2001, from 23 centres in ten European countries. Participant eligibility within each cohort was based on geographical or administrative boundaries. Participants were excluded if they had a cancer diagnosis before recruitment, had missing information for the NOVA food processing classification, or were within the top and bottom 1% for ratio of energy intake to energy requirement. Validated dietary questionnaires were used to obtain information on food and drink consumption. Participants with cancer were identified using cancer registries or during follow-up from a combination of sources, including cancer and pathology centres, health insurance records, and active follow-up of participants. We performed a substitution analysis to assess the effect of replacing 10% of processed foods and ultra-processed foods with 10% of minimally processed foods on cancer risk at 25 anatomical sites using Cox proportional hazard models. Findings 521 324 participants were recruited into EPIC, and 450 111 were included in this analysis (318 686 [70.8%] participants were female individuals and 131 425 [29.2%] were male individuals). In a multivariate model adjusted for sex, smoking, education, physical activity, height, and diabetes, a substitution of 10% of processed foods with an equal amount of minimally processed foods was associated with reduced risk of overall cancer (hazard ratio 0.96, 95% CI 0.95-0.97), head and neck cancers (0.80, 0.75-0.85), oesophageal squamous cell carcinoma (0.57, 0.51-0.64), colon cancer (0.88, 0.85-0.92), rectal cancer (0.90, 0.85-0.94), hepatocellular carcinoma (0.77, 0.68-0.87), and postmenopausal breast cancer (0.93, 0.90-0.97). The substitution of 10% of ultra-processed foods with 10% of minimally processed foods was associated with a reduced risk of head and neck cancers (0.80, 0.74-0.88), colon cancer (0.93, 0.89-0.97), and hepatocellular carcinoma (0.73, 0.62-0.86). Most of these associations remained significant when models were additionally adjusted for BMI, alcohol and dietary intake, and quality. Interpretation This study suggests that the replacement of processed and ultra-processed foods and drinks with an equal amount of minimally processed foods might reduce the risk of various cancer types. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/S2542-5196(23)00021-9 |
It is part of: | The Lancet Planetary Health, 2023, vol. 7, num. 3, p. e219-e232 |
URI: | http://hdl.handle.net/2445/201422 |
Related resource: | https://doi.org/10.1016/S2542-5196(23)00021-9 |
ISSN: | 2542-5196 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
PIIS2542519623000219.pdf | 512.46 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License