Title: | Risk factors for infections caused by carbapenem-resistant Enterobacterales: an international matched case-control-control study (EURECA) |
Author: | Pérez Galera, Salvador Bravo Ferrer, Jose M. Paniagua, María Kostyanev, Tomislav Kraker, Marlieke E.A. de Feifel, Jan Sojo Dorado, Jesús Schotsman, Joost Cantón, Rafael Daikos, George L. Carevic, Biljana Spyridis, Nikolaos Dorneanu, Olivia Michos, Athanasios Rosa, Francesco Giuseppe de Masanovic, Mileva Cavallo, Rossana Petrosillo, Nicola Dicaro, Antonio Landini, Maria Paola Matkovic, Dusan Lupse, Mihaela Tsiodras, Sotirios Kapisyzi, Perlat Blasi, Francesco Pasquale, Marta di Viscoli, Claudio Vata, Andrei Vince, Adriana Kurti, Arsim Tsigou, Evdoxia Maltezos, Efstratios Dragovac, Gorana Komnos, Apostolos Gogos, Charalampos Franzetti, Fabio Antonelli, Massimo Corneci, Dan Tomescu, Dana Díaz Pollán, Beatriz Georgescu, Anca Bukarica, Ljiljana Mitrović, Goran Krstić, Nataša Lukić Origüen Sabater, Julia Cano Yuste, Ángela Muñoz, Patricia Tan, Lionel K. Azap, Alpay Sancak, Banu Sahin, Arife Akalin, Halis Raka, Lul Bonten, Marc J. Hristea, Adriana Viale, Pierluigi Roilides, Emmanuel Akova, Murat Reguera, Jose María Valiente de Santis, Lucía Torre Cisneros, Julián Radulovic, Lili Kirakli, Cenk Gutiérrez Gutiérrez, Belén Shaw, Evelyn Falagas, Matthew E. Pintado, Vicente Goossens, Herman Rodríguez Baño, Jesús Pérez Camacho, Inés Serna, Almudena de la Monteau, Sophie Palomo, Virginia Soriano, Elena Gutiérrez, David Moreno, Elisa Palacios Baena, Zaira R. Chorafa, Elsa Morales, Isabel Maldonado, Natalia Frutos Adame, Azahara Plata, Antonio Ruiz Mesa, Juan Diego Sobrino Díaz, Beatriz Márquez Gómez, Ignacio Guzmán Puche, Julia Gracia Ahufinger, Irene Radovanovic, Ivana Pérez Nadales, Elena Torre Giménez, Julián Pyrpasopoulou, Athina Iosifidis, Elias Petrovic, Sladjana Margarita, Kyriakidou Cvetkovi, Slavica Melentijevic, Srdjan-Sanja Bicmen, Can Senol, Gunes Tubau, Fe Cámara, Jordi Gumucio, Victor Daniel Talapan, Daniela Bassoulis, Dimitris Deliolanis, John Gijón Cordero, Desirée Pitiriga, Vassiliki Ch. Triarides, Nikolaos Argiti, Efstathia Legakis, Nikolaos J. Ruiz Garbajosa, Patricia Bartoloni, Alessandro Medić, Deana Rossolini, Gian Maria Florescu, Simin-Aysel Nica, Maria Benea, Serban Prijić, Sanja Maričić Ciofi degli Atti, Marta Luisa Cantero Caballero, Mireia Parra Ramírez, Lina M. Korten, Volkan Bilgin, Hüseyin Dalekos, George N. Stefos, Aggelos |
Keywords: | Enterobacteriàcies Infeccions Enterobacteriaceae Infections |
Issue Date: | 1-Mar-2023 |
Publisher: | Elsevier BV |
Abstract: | Cases were patients with complicated urinary tract infection (cUTI), complicated intraabdominal (cIAI), pneumonia or bacteraemia from other sources (BSI-OS) due to CRE; control groups were patients with infection caused by carbapenem-susceptible Enterobacterales (CSE), and by non-infected patients, respectively. Matching criteria included type of infection for CSE group, ward and duration of hospital admission. Conditional logistic regression was used to identify risk factors. Findings Overall, 235 CRE case patients, 235 CSE controls and 705 non-infected controls were included. The CRE infections were cUTI (133, 56.7%), pneumonia (44, 18.7%), cIAI and BSI-OS (29, 12.3% each). Carbapenemase genes were found in 228 isolates: OXA-48/like, 112 (47.6%), KPC, 84 (35.7%), and metallo-beta-lactamases, 44 (18.7%); 13 produced two. The risk factors for CRE infection in both type of controls were (adjusted OR for CSE controls; 95% CI; p value) previous colonisation/infection by CRE (6.94; 2.74-15.53; <0.001), urinary catheter (1.78; 1.03-3.07; 0.038) and exposure to broad spectrum antibiotics, as categorical (2.20; 1.25-3.88; 0.006) and time-dependent (1.04 per day; 1.00-1.07; 0.014); chronic renal failure (2.81; 1.40-5.64; 0.004) and admission from home (0.44; 0.23-0.85; 0.014) were significant only for CSE controls. Subgroup analyses provided similar results. Interpretation The main risk factors for CRE infections in hospitals with high incidence included previous coloni-zation, urinary catheter and exposure to broad spectrum antibiotics. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.eclinm.2023.101871 |
It is part of: | eClinicalMedicine, 2023, vol. 57 |
URI: | http://hdl.handle.net/2445/201442 |
Related resource: | https://doi.org/10.1016/j.eclinm.2023.101871 |
ISSN: | 2589-5370 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
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