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http://hdl.handle.net/2445/203763
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DC Field | Value | Language |
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dc.contributor.author | Domingo Muelas, Ana | - |
dc.contributor.author | Duart Abadia, Pere | - |
dc.contributor.author | Morante Redolat, José Manuel | - |
dc.contributor.author | Jordán Pla, Antonio | - |
dc.contributor.author | Belenguer, Germán | - |
dc.contributor.author | Fabra Beser, Jaime | - |
dc.contributor.author | Paniagua Herranz, Lucía | - |
dc.contributor.author | Pérez Villalba, Ana | - |
dc.contributor.author | Álvarez Varela, Adrián | - |
dc.contributor.author | Barriga, Francisco M. | - |
dc.contributor.author | Gil Sanz, Cristina | - |
dc.contributor.author | Ortega, Felipe | - |
dc.contributor.author | Batlle, Eduard | - |
dc.contributor.author | Fariñas, Isabel | - |
dc.date.accessioned | 2023-11-17T11:39:45Z | - |
dc.date.available | 2023-11-17T11:39:45Z | - |
dc.date.issued | 2023-01-23 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2445/203763 | - |
dc.description.abstract | Neural stem cells (NSCs) in the adult murine subependymal zone balance their self-renewal capacity and glial identity with the potential to generate neurons during the lifetime. Adult NSCs exhibit lineage priming via pro-neurogenic fate determinants. However, the protein levels of the neural fate determinants are not sufficient to drive direct differentiation of adult NSCs, which raises the question of how cells along the neurogenic lineage avoid different conflicting fate choices, such as self-renewal and differentiation. Here, we identify RNA-binding protein MEX3A as a post-transcriptional regulator of a set of stemness associated transcripts at critical transitions in the subependymal neurogenic lineage. MEX3A regulates a quiescence-related RNA signature in activated NSCs that is needed for their return to quiescence, playing a role in the long-term maintenance of the NSC pool. Furthermore, it is required for the repression of the same program at the onset of neuronal differentiation. Our data indicate that MEX3A is a pivotal regulator of adult murine neurogenesis acting as a translational remodeller.© 2023. The Author(s). | - |
dc.format.extent | 17 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41467-023-36054-6 | - |
dc.relation.ispartof | Nature Communications, 2023, vol. 14, num. 1 | - |
dc.relation.uri | https://doi.org/10.1038/s41467-023-36054-6 | - |
dc.rights | cc by (c) Domingo Muelas, Ana et al., 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) | - |
dc.subject.classification | Neurogenètica | - |
dc.subject.classification | RNA | - |
dc.subject.other | Neurogenetics | - |
dc.subject.other | RNA | - |
dc.title | Post-transcriptional control of a stemness signature by RNA-binding protein MEX3A regulates murine adult neurogenesis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-11-16T12:53:03Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 6574853 | - |
dc.identifier.pmid | 36690670 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
Files in This Item:
File | Description | Size | Format | |
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NatCommun_Domingo-Muelas et al_2023.pdf | 3.92 MB | Adobe PDF | View/Open |
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