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http://hdl.handle.net/2445/204381
Title: | A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk |
Author: | Aglago, Elom K. Kim, Andre Lin, Yi Qu, Conghui Evangelou, Marina Ren, Yu Morrison, John Albanes, Demetrius Arndt, Volker Barry, Elizabeth L. Baurley, James W. Berndt, Sonja I. Bien, Stephanie A. Bishop, D. Timothy Bouras, Emmanouil Brenner, Hermann Buchanan, Daniel D. Budiarto, Arif Carreras Torres, Robert Casey, Graham Cenggoro, Wawan Tjeng Chan, Andrew T. Chang-Claude, Jenny Chen, Xuechen Conti, David V. Devall, Matthew Díez Obrero, Virginia Dimou, Niki Drew, David Figueiredo, Jane C. Gallinger, Steven Giles, Graham G. Gruber, Stephen B. Gsur, Andrea Gunter, Marc J. Hampel, Heather Harlid, Sophia Hidaka, Akihisa Harrison, Tabitha A. Hoffmeister, Michael Huyghe, Jeroen R. Jenkins, Mark A. Jordahl, Kristina Joshi, Amit D. Kawaguchi, Eric S. Keku, Temitope O. Kundaje, Anshul Larsson, Susanna C. Marchand, Loic Le Lewinger, Juan Pablo Li, Li Lynch, Brigid M. Mahesworo, Bharuno Mandic, Marko Obón Santacana, Mireia Moreno Aguado, Víctor Murphy, Neil Nan, Hongmei Nassir, Rami Newcomb, Polly A. Ogino, Shuji Ose, Jennifer Pai, Rish K. Palmer, Julie R. Papadimitriou, Nikos Pardamean, Bens Peoples, Anita R. Platz, Elizabeth A. Potter, John D. Prentice, Ross L. Rennert, Gad Ruiz-Narvaez, Edward Sakoda, Lori C. Scacheri, Peter C. Schmit, Stephanie L. Schoen, Robert E. Shcherbina, Anna Slattery, Martha L. Stern, Mariana C. Su, Yu Ru Tangen, Catherine M. Thibodeau, Stephen N. Thomas, Duncan C. Tian, Yu Ulrich, Cornelia M. Duijnhoven, Franzel J.B. van Guelpen, Bethany van Visvanathan, Kala Vodicka, Pavel Wang, Jun White, Emily Wolk, Alicja Woods, Michael O. Wu, Anna H. Zemlianskaia, Natalia Hsu, Li Gauderman, W. James Peters, Ulrike Tsilidis, Konstantinos K. Campbell, Peter T. |
Keywords: | Càncer colorectal Obesitat Colorectal cancer Obesity |
Issue Date: | 30-May-2023 |
Publisher: | American Association for Cancer Research (AACR) |
Abstract: | Colorectal cancer risk can be impacted by genetic, environmental, and lifestyle factors, including diet and obesity. Geneenvironment interactions (G x E) can provide biological insights into the effects of obesity on colorectal cancer risk. Here, we assessed potential genome-wide G x E interactions between body mass index (BMI) and common SNPs for colorectal cancer risk using data from 36,415 colorectal cancer cases and 48,451 controls from three international colorectal cancer consortia (CCFR, CORECT, and GECCO). The G x E tests included the conventional logistic regression using multiplicative terms (one degree of freedom, 1DF test), the two-step EDGE method, and the joint 3DF test, each of which is powerful for detecting G x E interactions under specific conditions. BMI was associated with higher colorectal cancer risk. The two-step approach revealed a statistically significant GxBMI interaction located within the Formin 1/Gremlin 1 (FMN1/GREM1) gene region (rs58349661). This SNP was also identified by the 3DF test, with a suggestive statistical significance in the 1DF test. Among participants with the CC genotype of rs58349661, overweight and obesity categories were associated with higher colorectal cancer risk, whereas null associations were observed across BMI categories in those with the TT genotype. Using data from three large international consortia, this study discovered a locus in the FMN1/GREM1 gene region that interacts with BMI on the association with colorectal cancer risk. Further studies should examine the potential mechanisms through which this locus modifies the etiologic link between obesity and colorectal cancer. |
Note: | Reproducció del document publicat a: https://doi.org/10.1158/0008-5472.CAN-22-3713 |
It is part of: | Cancer Research, 2023, vol. 83, num. 15, p. 2572-2583 |
URI: | http://hdl.handle.net/2445/204381 |
Related resource: | https://doi.org/10.1158/0008-5472.CAN-22-3713 |
ISSN: | 1538-7445 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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