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Title: | Chromatin activation profiling of stereotyped chronic lymphocytic leukemias reveals a subset 8-specific signature |
Author: | Tsagiopoulou, Maria Chapaprieta, Vicente Russiñol, Nuria García Torre, Beatriz Pechlivanis, Nikolaos Nadeu, Ferran Papakonstantinou, Nikos Stavroyianni, Niki Chatzidimitriou, Anastasia Psomopoulos, Fotis Campo Güerri, Elias Stamatopoulos, Kostas Martín Subero, José Ignacio |
Keywords: | Leucèmia limfocítica crònica Cromatina Chronic lymphocytic leukemia Chromatin |
Issue Date: | 15-Jun-2023 |
Abstract: | The chromatin activation landscape of chronic lymphocytic leukemia (CLL) with stereo-typed B-cell receptor immunoglobulin is currently unknown. In this study, we report the results of a whole-genome chromatin profiling of histone 3 lysine 27 acetylation of 22 CLLs from major subsets, which were compared against nonstereotyped CLLs and normal B-cell subpopulations. Although subsets 1, 2, and 4 did not differ much from their non-stereotyped CLL counterparts, subset 8 displayed a remarkably distinct chromatin acti-vation profile. In particular, we identified 209 de novo active regulatory elements in this subset, which showed similar patterns with U-CLLs undergoing Richter transformation. These regions were enriched for binding sites of 9 overexpressed transcription factors. In 78 of 209 regions, we identified 113 candidate overexpressed target genes, 11 regions being associated with more than 2 adjacent genes. These included blocks of up to 7 genes, suggesting local coupregulation within the same genome compartment. Our findings further underscore the uniqueness of subset 8 CLL, notable for the highest risk of Richter's transformation among all CLLs and provide additional clues to decipher the molecular basis of its clinical behavior. |
Note: | Reproducció del document publicat a: https://doi.org/10.1182/blood.2022016587 |
It is part of: | Blood, 2023, vol. 141, num. 24, p. 2955-2960 |
URI: | http://hdl.handle.net/2445/204390 |
Related resource: | https://doi.org/10.1182/blood.2022016587 |
ISSN: | 1528-0020 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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Tsagiopoulou et al_accepted version 2023.pdf | 1.83 MB | Adobe PDF | View/Open Request a copy |
Document embargat fins el 15-6-2024
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