Title: | Common Genetic Variation and Age of Onset of Anorexia Nervosa |
Author: | Watson, Hunna J. Thornton, Laura M. Yilmaz, Zeynep Baker, Jessica H. Coleman, Jonathan R. I. Adan, Roger A. H. Alfredsson, Lars Andreassen, Ole A. Ask, Helga Berrettini, Wade H. Boehnke, Michael Boehm, Ilka Boni, Claudette Buehren, Katharina Bulant, Josef Burghardt, Roland Chang, Xiao Cichon, Sven Cone, Roger D. Courtet, Philippe Crow, Scott Crowley, James J. Danner, Unna N. Zwaan, Martina de Dedoussis, George DeSocio, Janiece E. Dick, Danielle M. Dikeos, Dimitris Dina, Christian Djurovic, Srdjan Dmitrzak-Weglarz, Monika Docampo Martínez, Elisa Duriez, Philibert Egberts, Karin Ehrlich, Stefan Eriksson, Johan G. Escaramís Babiano, Geòrgia Esko, Tõnu Estivill, Xavier, 1955- Farmer, Anne Fernández Aranda, Fernando Fichter, Manfred M. Föcker, Manuel Foretova, Lenka Forstner, Andreas J. Frei, Oleksandr Gallinger, Steven Giegling, Ina Giuranna, Johanna Gonidakis, Fragiskos Gorwood, Philip Gratacòs, Mònica Guillaume, Sébastien Guo, Yiran Hakonarson, Hakon Hauser, Joanna Havdahl, Alexandra Hebebrand, Johannes Helder, Sietske G. Herms, Stefan Herpertz-Dahlmann, Beate Herzog, Wolfgang Hinney, Anke Hübel, Christopher Hudson, James I. Imgart, Hartmut Jamain, Stephanie Janout, Vladimir Jiménez Murcia, Susana Jones, Ian R. Julià, Antonio Kalsi, Gursharan Kaminská, Deborah Kaprio, Jaakko Karhunen, Leila Kas, Martien J. H. Keel, Pamela P. Kennedy, James L. Keski-Rahkonen, Anna Kiezebrink, Kirsty Klareskog, Lars Klump, Kelly L. Knudsen, Gun Peggy S. Via, Maria C. La Le Hellard, Stephanie Leboyer, Marion Li, Dong Lilenfeld, Lisa Lin, Bochao Lissowska, Jolanta Luykx, Jurjen Magistretti, Pierre J. Maj, Mario Marsal Barril, Sara Marshall, Christian R. Mattingsdal, Morten Meulenbelt, Ingrid Micali, Nadia Mitchell, Karen S. Monteleone, Alessio Maria Monteleone, Palmiero Myers, Richard Navratilova, Marie Ntalla, Ionna O'Toole, Julie K. Ophoff, Roel A. Padyukov, Leonid Pantel, Jacques Papezova, Hana Pinto, Dalila Raevuori, Anu Ramoz, Nicolas Reichborn-Kjennerud, Ted Ricca, Valdo Ripatti, Samuli Ripke, Stephan Ritschel, Franziska Roberts, Marion Rotondo, Alessandro Rujescu, D. Rybakowski, Filip Scherag, André Scherer, Stephen W. Schmidt, Ulrike Scott, Laura J. Seitz, Jochen Silén, Yasmina Slachtova, Lenka Slagboom, P. Eline Slof-Op't Landt, Margarita C. T. Slopien, Agnieszka Sorbi, Sandro Swiqtkowska, Beata Tortorella, Alfonso Tozzi, Federica Treasure, Janet Tsitsika, Artemis Tyszkiewicz-Nwafor, Marta Tziouvas, Konstantinos Elburg, Annemarie A. van Furth, Eric F. van Walton, Esther Widen, Elisabeth Zerwas, Stephanie Zipfel, Stephan Bergen, Andrew W. Boden, Joseph M. Brandt, Harry Crawford, Steven Halmi, Katherine A. Horwood, L. John Johnson, Craig Kaplan, Allan S. Kaye, Walter H. Mitchell, James E. Olsen, Catherine M. Pearson, John F. Pedersen, Nancy L. Strober, Michael Werge, Thomas Whiteman, David C. Woodside, D. Blake Gordon, Scott Maguire, Sarah Larsen, Janne T. Parker, Richard Petersen, Liselotte V. Jordan, Jennifer Kennedy, Martin Wade, Tracey D. Birgegård, Andreas Lichtenstein, Paul Landén, Mikael Martin, Nicholas G. Mortensen, Preben Bo Breen, Gerome Bulik, Cynthia M. |
Keywords: | Anorèxia nerviosa Genètica Lleis de Mendel Anorexia nervosa Genetics Mendel's law |
Issue Date: | 1-Oct-2022 |
Publisher: | Elsevier B.V. |
Abstract: | Background Genetics and biology may influence the age of onset of anorexia nervosa (AN). The aims of this study were to determine whether common genetic variation contributes to age of onset of AN and to investigate the genetic associations between age of onset of AN and age at menarche. Methods A secondary analysis of the Psychiatric Genomics Consortium genome-wide association study (GWAS) of AN was performed, which included 9335 cases and 31,981 screened controls, all from European ancestries. We conducted GWASs of age of onset, early-onset AN (<13 years), and typical-onset AN, and genetic correlation, genetic risk score, and Mendelian randomization analyses. Results Two loci were genome-wide significant in the typical-onset AN GWAS. Heritability estimates (single nucleotide polymorphism–h2) were 0.01–0.04 for age of onset, 0.16–0.25 for early-onset AN, and 0.17–0.25 for typical-onset AN. Early- and typical-onset AN showed distinct genetic correlation patterns with putative risk factors for AN. Specifically, early-onset AN was significantly genetically correlated with younger age at menarche, and typical-onset AN was significantly negatively genetically correlated with anthropometric traits. Genetic risk scores for age of onset and early-onset AN estimated from independent GWASs significantly predicted age of onset. Mendelian randomization analysis suggested a causal link between younger age at menarche and early-onset AN. Conclusions Our results provide evidence consistent with a common variant genetic basis for age of onset and implicate biological pathways regulating menarche and reproduction. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.bpsgos.2021.09.001 |
It is part of: | Biological Psychiatry: Global Open Science, 2022, vol. 2, num.4, p. 368-378 |
URI: | http://hdl.handle.net/2445/205025 |
Related resource: | https://doi.org/10.1016/j.bpsgos.2021.09.001 |
ISSN: | 2667-1743 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
|