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http://hdl.handle.net/2445/205225
Title: | Reproductive and hormonal factors and risk of renal cell carcinoma among women in the European Prospective Investigation into Cancer and Nutrition |
Author: | Clasen, Joanna L. Mabunda, Rita Heath, Alicia K. Kaaks, Rudolf Katzke, Verena Schulze, Matthias B. Birukov, Anna Tagliabue, Giovanna Chiodini, Paolo Tumino, Rosario Milani, Lorenzo Braaten, Tonje Gram, Inger Lukic, Marko Luján Barroso, Leila Rodriguez Barranco, Miguel Chirlaque, María Dolores Ardanaz, Eva Amiano, Pilar Manjer, Jonas Huss, Linnea Ljungberg, Börje Travis, Ruth Smith‐Byrne, Karl Gunter, Marc Johansson, Matthias Rinaldi, Sabina Weiderpass, Elisabete Riboli, Elio Cross, Amanda J. Muller, David C. |
Keywords: | Càncer de ronyó Hormones Factors de risc en les malalties Renal cancer Hormones Risk factors in diseases |
Issue Date: | 3-Jun-2023 |
Publisher: | Wiley |
Abstract: | PurposeThe incidence of small intestinal cancer (SIC) is increasing, however, its aetiology remains unclear due to a lack of data from large-scale prospective cohorts. We examined modifiable risk factors in relation to SIC overall and by histological subtype.MethodsWe analysed 450,107 participants enrolled in the European Prospective Investigation into Cancer and Nutrition cohort. Cox proportional hazards models were used to estimate univariable and multivariable hazard ratios (HRs) and 95% confidence intervals (CIs).ResultsDuring an average of 14.1 years of follow-up, 160 incident SICs (62 carcinoids, 51 adenocarcinomas) were identified. Whilst univariable models revealed a positive association for current versus never smokers and SIC (HR, 95% CI: 1.77, 1.21-2.60), this association attenuated in multivariable models. In energy-adjusted models, there was an inverse association across vegetable intake tertiles for SIC overall (HRT3vsT1, 95% CI: 0.48, 0.32-0.71, p-trend: < 0.001) and for carcinoids (HRT3vsT1, 95% CI: 0.44, 0.24-0.82, p-trend: 0.01); however, these attenuated in multivariable models. Total fat was also inversely associated with total SIC and both subtypes but only in the second tertile (SIC univariable HRT2vsT1, 95% CI: 0.57, 0.38-0.84; SIC multivariable HRT2vsT1, 95% CI: 0.55, 0.37-0.81). Physical activity, intake of alcohol, red or processed meat, dairy products, or fibre were not associated with SIC.ConclusionThese exploratory analyses found limited evidence for a role of modifiable risk factors in SIC aetiology. However, sample size was limited, particularly for histologic subtypes; therefore, larger studies are needed to delineate these associations and robustly identify risk factors for SIC. |
Note: | Reproducció del document publicat a: https://doi.org/10.1002/cam4.6207 |
It is part of: | Cancer Medicine, 2023, vol. 12, num. 14, p. 15588-15600 |
URI: | http://hdl.handle.net/2445/205225 |
Related resource: | https://doi.org/10.1002/cam4.6207 |
ISSN: | 2045-7634 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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