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Title: | Integrated analysis of randomized controlled trials evaluating bortezomib + lenalidomide + dexamethasone or bortezomib + thalidomide + dexamethasone induction in transplant-eligible newly diagnosed multiple myeloma |
Author: | Rosiñol, Laura Hebraud, Benjamin Oriol, Albert Colin, Anne Laurène Ríos Tamayo, Rafael Hulin, Cyrille Blanchard, María Jesús Caillot, Denis Sureda, Anna Hernández, Miguel Teodoro Arnulf, Bertrand Mateos, Maria Victoria Macro, Margaret San Miguel, Jesús Belhadj, Karim Lahuerta, Juan José Garelik, M. Brigid Bladé, Joan Moreau, Philippe |
Keywords: | Mieloma múltiple Terapèutica Multiple myeloma Therapeutics |
Issue Date: | 2-Nov-2023 |
Publisher: | Frontiers Media SA |
Abstract: | ObjectiveProviding the most efficacious frontline treatment for newly diagnosed multiple myeloma (NDMM) is critical for patient outcomes. No direct comparisons have been made between bortezomib + lenalidomide + dexamethasone (VRD) and bortezomib + thalidomide + dexamethasone (VTD) induction regimens in transplant-eligible NDMM.MethodsAn integrated analysis was performed using patient data from four trials meeting prespecified eligibility criteria: two using VRD (PETHEMA GEM2012 and IFM 2009) and two using VTD (PETHEMA GEM2005 and IFM 2013-04).ResultsThe primary endpoint was met, with VRD demonstrating a noninferior rate of at least very good partial response (>= VGPR) after induction vs VTD. GEM comparison demonstrated improvement in the >= VGPR rate after induction for VRD vs VTD (66.3% vs 51.2%; P = .00281) that increased after transplant (74.4% vs 53.5%). Undetectable minimal residual disease rates post induction (46.7% vs 34.9%) and post transplant (62.4% vs 47.3%) support the benefit of VRD vs VTD. Treatment-emergent adverse events leading to study and/or treatment discontinuation were less frequent with VRD (3%, GEM2012; 6%, IFM 2009) vs VTD (11%, IFM 2013-04).ConclusionThese results supported the benefit of VRD over VTD for induction in transplant-eligible patients with NDMM. The trials included are registered with ClinicalTrials.gov (NCT01916252, NCT01191060, NCT00461747, and NCT01971658). |
Note: | Reproducció del document publicat a: https://doi.org/10.3389/fonc.2023.1197340 |
It is part of: | Frontiers in Oncology, 2023, vol. 13 |
URI: | http://hdl.handle.net/2445/205802 |
Related resource: | https://doi.org/10.3389/fonc.2023.1197340 |
ISSN: | 2234-943X |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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fonc-13-1197340.pdf | 1.64 MB | Adobe PDF | View/Open |
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