Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/206220
Title: | Adipose Tissue Protects against Hepatic Steatosis in Male Rats Fed a High-Fat Diet plus Liquid Fructose: Sex-Related Differences |
Author: | Bentanachs Raset, Roger Blanco, Laia Montesinos, Maria Sala Vila, Aleix Lazaro, Iolanda Jose Rodríguez-Morató Sánchez Peñarroya, Rosa M. Laguna Egea, Juan Carlos Roglans i Ribas, Núria Alegret i Jordà, Marta |
Keywords: | Fructosa Teixit adipós Fructose Adipose tissues |
Issue Date: | 1-Sep-2023 |
Publisher: | MDPI |
Abstract: | Non-alcoholic fatty liver disease is a sexual dimorphic disease, with adipose tissue playing an essential role. Our previous work showed that female rats fed a high-fat high-fructose diet devoid of cholesterol (HFHFr) developed simple hepatic steatosis dissociated from obesity. This study assessed the impact of the HFHFr diet on the male rat metabolism compared with data obtained for female rats. A total of 16 Sprague Dawley (SD) male rats were fed either a control (standard rodent chow and water) or HFHFr (high-fat diet devoid of cholesterol, plus 10% fructose in drinking water) diet for 3 months. Unlike female rats, and despite similar increases in energy consumption, HFHFr males showed increased adiposity and hyperleptinemia. The expression of hormone-sensitive lipase in the subcutaneous white adipose tissue was enhanced, leading to high free fatty acid and glycerol serum levels. HFHFr males presented hypertriglyceridemia, but not hepatic steatosis, partially due to enhanced liver PPARα-related fatty acid β-oxidation and the VLDL-promoting effect of leptin. In conclusion, the SD rats showed a sex-related dimorphic response to the HFHFr diet. Contrary to previous results for HFHFr female rats, the male rats were able to expand the adipose tissue, increase fatty acid catabolism, or export it as VLDL, avoiding liver lipid deposition. Keywords: adipose tissue; fructose; high-fat diet; leptin; non-esterified fatty acids. |
Note: | Reproducció del document publicat a: https://doi.org/doi: 10.3390/nu15183909. |
It is part of: | Nutrients, 2023, vol. 15, num.8, p. 3909 |
URI: | http://hdl.handle.net/2445/206220 |
Related resource: | https://doi.org/doi: 10.3390/nu15183909. |
ISSN: | 2072-6643 |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
833668.pdf | 3.45 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License