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http://hdl.handle.net/2445/206963
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DC Field | Value | Language |
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dc.contributor.author | Sans-Fons, Gloria | - |
dc.contributor.author | Yeramian, Andrée | - |
dc.contributor.author | Pereira Lopes, Selma Patrícia | - |
dc.contributor.author | Santamaria Babí, Luis F. | - |
dc.contributor.author | Modolell, Manuel | - |
dc.contributor.author | Lloberas Cavero, Jorge | - |
dc.contributor.author | Celada Cotarelo, Antonio | - |
dc.date.accessioned | 2024-02-01T14:25:39Z | - |
dc.date.available | 2024-02-01T14:25:39Z | - |
dc.date.issued | 2013-06-01 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.uri | http://hdl.handle.net/2445/206963 | - |
dc.description.abstract | Host genetic factors play a crucial role in immune response. To determine whether the differences betweenC57Bl/6 and BALB-C mice are due only to the production of cytokines by T-helper 1 cells or T-helper 2 cells,we obtained bone marrow–derived macrophages from both strains and incubated them with these cytokines.Although the induction of Nos2 and Arg1 was similar in the 2 strains, infectivity to <em>Leishmania major</em> differed,as did macrophage uptake of arginine, which was higher in BALB-C macrophages. The levels of interferon γ–and interleukin 4–dependent induction of the cationic amino acid transporter SLC7A2 (also known as “cationicamino acid transporter 2,” or “CAT2”) were decreased in macrophages from C57Bl/6 mice. This reductionwas a result of a deletion in the promoter of one of the 4 AGGG repeats. These results demonstrate that theavailability of arginine controls critical aspects of macrophage activation and reveal a factor for susceptibility to Leishmania infection. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1093/infdis/jit084 | - |
dc.relation.ispartof | Journal of Infectious Diseases, 2013, vol. 207, num.11, p. 1684-1693 | - |
dc.relation.uri | https://doi.org/10.1093/infdis/jit084 | - |
dc.rights | (c) Sans-Fons, G. et al., 2013 | - |
dc.source | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) | - |
dc.subject.classification | Macròfags | - |
dc.subject.classification | Leishmània | - |
dc.subject.classification | Aminoàcids | - |
dc.subject.other | Macrophages | - |
dc.subject.other | Leishmania | - |
dc.subject.other | Amino acids | - |
dc.title | Arginine transport is impaired in C57Bl/6 mouse macrophages as a result of a deletion in the promoter of slc7a2 (CAT2) and Leishmania infection is reduced | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 618924 | - |
dc.date.updated | 2024-02-01T14:25:39Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) |
Files in This Item:
File | Description | Size | Format | |
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159181.pdf | 2.5 MB | Adobe PDF | View/Open |
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