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http://hdl.handle.net/2445/207100
Title: | Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy |
Author: | Laporta-Hoyos, Olga Fiori, Simona Pannek, Kerstin Ballester Plané, Júlia Leiva Ureña, David Reid, Lee Pagnozzi, Alex M. Vázquez, Elida Delgado, Ignacio Macaya Ruiz, Alfons Pueyo Benito, Roser Boyd, Roslyn |
Keywords: | Paràlisi cerebral Imatges per ressonància magnètica Cognició Lesions cerebrals Cerebral palsy Magnetic resonance imaging Cognition Brain damage |
Issue Date: | 20-Jun-2018 |
Publisher: | Elsevier |
Abstract: | Purpose: To characterise brain lesions in dyskinetic cerebral palsy (DCP) using the semi-quantitative scale for structural MRI (sqMRI) and to investigate their relationship with motor, communication and cognitive function. Materials and methods: Thirty-nine participants (19 females, median age 21y) with DCP were assessed in terms of motor function, communication and a variety of cognitive domains. Whole-head magnetic resonance imaging (MRI) was performed including T1-MPRAGE, T2 turbo spin echo (axial plane), and fluid attenuated inversion recovery images (FLAIR). A child neurologist visually assessed images for brain lesions and scored these using the sqMRI. Ordinal, Poisson and binomial negative regression models identified which brain lesions accounted for clinical outcomes. Results: Brain lesions were most frequently located in the ventral posterior lateral thalamus and the frontal lobe. Gross (B = 0.180, p < .001; B = 0.658, p < .001) and fine (B = 0.136, p = .003; B = 0.540, p < .001) motor function were associated with global sqMRI score and parietal involvement. Communication functioning was associated with putamen involvement (B = 0.747, p < .028). Intellectual functioning was associated with global sqMRI score and posterior thalamus involvement (B = -0.018, p < .001; B = -0.192, p < .001). Selective attention was associated with global sqMRI score (B = -0.035, p < .001), parietal (B = -0.063, p = .023), and corpus callosum involvement (B = -0.448, p < .001). Visuospatial and visuoperceptive abilities were associated with global sqMRI score (B = -0.078, p = .007) and medial dorsal thalamus involvement (B = -0.139, p < .012), respectively. Conclusions: Key clinical outcomes in DCP are associated with specific observable brain lesions as indexed by a simple lesion scoring system that relies only on standard clinical MRI. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.nicl.2018.06.015 |
It is part of: | Neuroimage-Clinical, 2018, vol. 19, p. 892-900 |
URI: | http://hdl.handle.net/2445/207100 |
Related resource: | https://doi.org/10.1016/j.nicl.2018.06.015 |
ISSN: | 2213-1582 |
Appears in Collections: | Articles publicats en revistes (Psicologia Clínica i Psicobiologia) Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa) |
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