Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/207186
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Rabanal Anglada, Francesc | - |
dc.contributor.author | Candelario Ribas, Hermes | - |
dc.date.accessioned | 2024-02-06T16:09:51Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.uri | http://hdl.handle.net/2445/207186 | - |
dc.description | Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2023, Tutor: Francesc Rabanal Anglada | ca |
dc.description.abstract | The overuse of antibiotics has increase the resistance of bacteria to these compounds. Thus the need to develop new antibiotics has risen in the recent years. Antimicrobial peptides have become promising candidates for this issue. Polymyxin and murepavadin are among them, but are used only as last resource antibiotics. The aim of this work is to synthesise novel antibiotics that use these compound as scaffolds by solid phase peptide synthesis (SPPS). These analogues have been designed for improving their activity and reduce their toxicity. Secondly, the cyclization by a disulphide bond of these peptides has been studied as well as their impurities. Finally, these peptides have been purified by RP-HPLC and characterized by ESI mass spectroscopy. Furthermore, the antimicrobial activity of the analogues has been evaluated by minimum inhibitory concentration (MIC) determination. This research contributes into the development of novel antibiotics to combat multidrug-resistant bacteria | ca |
dc.format.extent | 60 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.rights | cc-by-nc-nd (c) Candelario, 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Treballs Finals de Grau (TFG) - Química | - |
dc.subject.classification | Pèptid antimicrobià | cat |
dc.subject.classification | Antibiòtics | cat |
dc.subject.classification | Síntesi de pèptids | cat |
dc.subject.classification | Treballs de fi de grau | cat |
dc.subject.other | Antimicrobial peptides | eng |
dc.subject.other | Antibiotics | eng |
dc.subject.other | Peptide synthesis | eng |
dc.subject.other | Bachelor's theses | - |
dc.title | Synthesis of cyclic peptide antibiotics and related compounds | eng |
dc.title.alternative | Síntesis de antibióticos peptídicos cíclicos i compuestos relacionados | ca |
dc.type | info:eu-repo/semantics/bachelorThesis | ca |
dc.rights.accessRights | info:eu-repo/semantics/embargoedAccess | ca |
dc.embargo.lift | 2026-02-06 | - |
dc.date.embargoEndDate | info:eu-repo/date/embargoEnd/2026-02-06 | ca |
Appears in Collections: | Treballs Finals de Grau (TFG) - Química |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
TFG_Qu_CandelarioRibasHermes.pdf | 2.55 MB | Adobe PDF | View/Open Request a copy |
Document embargat fins el 6-2-2026
This item is licensed under a Creative Commons License