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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/207639
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dc.contributor.authorRodríguez Urgellés, Ened-
dc.contributor.authorCasas Torremocha, Diana-
dc.contributor.authorSancho Balsells, Anna-
dc.contributor.authorBallasch, Ivan-
dc.contributor.authorGarcía-García, Esther-
dc.contributor.authorMiquel Rio, Lluís-
dc.contributor.authorManasanch, Arnau-
dc.contributor.authorDel Castillo, Ignacio-
dc.contributor.authorChen, Wanqi-
dc.contributor.authorPupak, Anika-
dc.contributor.authorBrito, Verónica-
dc.contributor.authorTornero, Daniel-
dc.contributor.authorRodríguez Allué, Manuel José-
dc.contributor.authorBortolozzi, Analía-
dc.contributor.authorSánchez-Vives, María Victoria-
dc.contributor.authorGiralt Torroella, Albert-
dc.contributor.authorAlberch i Vié, Jordi-
dc.date.accessioned2024-02-15T16:27:13Z-
dc.date.issued2023-11-21-
dc.identifier.issn1420-682X-
dc.identifier.urihttp://hdl.handle.net/2445/207639-
dc.description.abstractHere, we demonstrate in a HD mouse model a clear and early thalamo-striatal aberrant connectivity associated with a reduction of thalamic Foxp2 levels. Recovering thalamic Foxp2 levels in the mouse rescued motor coordination and sensory skills concomitant with an amelioration of neuropathological features and with a repair of the structural and functional connectivity through a restoration of neurotransmitter release. In addition, reduction of thalamic Foxp2 levels in wild type mice induced HD-like phenotypes.-
dc.format.extent25 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherSpringer Verlag-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1007/s00018-023-05015-z-
dc.relation.ispartofCellular and Molecular Life Sciences, 2023, vol. 80, num.12-
dc.relation.urihttps://doi.org/10.1007/s00018-023-05015-z-
dc.rightscc by (c) Rodríguez Urgellés, Ened et al., 2023-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.sourceArticles publicats en revistes (Biomedicina)-
dc.subject.classificationCorea de Huntington-
dc.subject.classificationHipotàlem-
dc.subject.classificationGanglis basals-
dc.subject.classificationNeurones sensorials-
dc.subject.classificationElectrofisiologia-
dc.subject.otherHuntington's chorea-
dc.subject.otherHypothalamus-
dc.subject.otherBasal ganglia-
dc.subject.otherSensory neurons-
dc.subject.otherElectrophysiology-
dc.titleThalamic Foxp2 regulates output connectivity and sensory‑motor impairments in a model of Huntington’s Disease-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.doi10.1007/s00018-023-05015-z-
dc.identifier.idgrec741899-
dc.date.updated2024-02-15T16:27:13Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.date.embargoEndDateinfo:eu-repo/date/embargoEnd/2024-11-20-
dc.identifier.pmid37987826-
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Biomedicina)

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